catalog number :
MBS852106
products full name :
CNGA2 Antibody
products short name :
CNGA2
products name syn :
CNCA; CNCA1; CNCG2; CNG channel 2; CNG-2; CNG2; cyclic nucleotide-gated cation channel 2
other names :
cyclic nucleotide-gated olfactory channel; Cyclic nucleotide-gated olfactory channel; cyclic nucleotide-gated olfactory channel; CNG-2; CNG channel alpha-2; cyclic nucleotide-gated channel alpha-2; cyclic nucleotide-gated cation channel 2; cyclic-nucleotide-gated cation channel 2; cyclic-nucleotide-gated olfactory channel; cyclic nucleotide gated channel alpha 2; Cyclic nucleotide-gated cation channel 2; Cyclic nucleotide-gated channel alpha-2; CNG channel alpha-2; CNG-2; CNG2
products gene name :
CNGA2
other gene names :
CNGA2; CNGA2; CNCA; CNG2; CNCA1; OCNC1; OCNCa; OCNCALPHA; CNCA; CNCA1; CNCG2; CNG channel alpha-2; CNG-2; CNG2
uniprot entry name :
CNGA2_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
CNGA2 antibody detects endogenous levels of total CNGA2 protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20 degree C for 1 year
tested application :
Immunofluorescence (IF), ELISA (EIA)
app notes :
IF: 1:100~1:500, ELISA: 1:40000
other info1 :
Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 92%, Positives = 100%); Rat (Identities = 92%, Positives = 100%)
other info2 :
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human CNGA2. Pathway: Channel
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
The MGC Project Team; Genome Res. 14:2121-2127(2004). Distler M., Neuropharmacology 33:1275-1282(1994). Sjoeblom T., Science 314:268-274(2006). ------------------------------------------------------------------------------------------------------------------------------------------
ncbi acc num :
NP_005131.1
ncbi gb acc num :
NM_005140.1
ncbi mol weight :
76,048 Da
ncbi pathways :
CAMP Signaling Pathway (1017634); CAMP Signaling Pathway (1019520)
ncbi summary :
The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]
uniprot summary :
CNGA2: Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily. Protein type: Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: Xq27. Cellular Component: Golgi membrane; integral to plasma membrane. Molecular Function: calmodulin binding; voltage-gated potassium channel activity; intracellular cGMP activated cation channel activity; cGMP binding; cAMP binding. Biological Process: phototransduction, visible light; regulation of membrane potential; organelle organization and biogenesis; sensory perception of smell