catalog number :
MBS8519847
products full name :
CPI-17 (phospho Thr38) Polyclonal Antibody
products short name :
[CPI-17]
products name syn :
[PPP1R14A; CPI17; PPP1INL; Protein phosphatase 1 regulatory subunit 14A; 17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa-CPI-17]
other names :
[protein phosphatase 1 regulatory subunit 14A isoform 2; Protein phosphatase 1 regulatory subunit 14A; protein phosphatase 1 regulatory subunit 14A; protein phosphatase 1 regulatory inhibitor subunit 14A; 17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17]
products gene name :
[CPI-17]
other gene names :
[PPP1R14A; PPP1R14A; CPI17; CPI-17; PPP1INL; CPI17; PPP1INL; CPI-17]
reactivity :
Human, Mouse, Rat.
specificity :
Phospho-CPI-17 (T38) Polyclonal antibody detects endogenous levels of CPI-17 protein only when phosphorylated at T38.
purity :
The antibody was affiniy-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
storage stability :
Store at -20°C/1 year.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA).
app notes :
Western Blot (WB) 1/500-1/2000. Immunohistochemistry (IHC) 1/100-1/300. ELISA (EIA)1/20000. Not yet tested in other applications.
other info1 :
Immunogen: Synthesized peptide derived from human CPI-17 around the phosphorylation site of T38.
ncbi acc num :
NP_001230876.1
ncbi gb acc num :
NM_001243947.1
ncbi pathways :
Vascular Smooth Muscle Contraction Pathway (96530); Vascular Smooth Muscle Contraction Pathway (96866)
ncbi summary :
The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]
uniprot summary :
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.