catalog number :
MBS8518708
products full name :
CHRNB4 Antibody
products short name :
[CHRNB4]
other names :
[neuronal acetylcholine receptor subunit beta-4 isoform 1; Neuronal acetylcholine receptor subunit beta-4; neuronal acetylcholine receptor subunit beta-4; cholinergic receptor nicotinic beta 4 subunit]
products gene name :
[CHRNB4]
other gene names :
[CHRNB4; CHRNB4]
image1 heading :
Western Blot (WB)
ncbi acc num :
NP_000741.1
ncbi gb acc num :
NM_000750.4
ncbi mol weight :
25,862 Da
ncbi pathways :
Acetylcholine Binding And Downstream Events Pathway (106535); Activation Of Nicotinic Acetylcholine Receptors Pathway (161027); Cholinergic Synapse Pathway (217716); Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway (161029); Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway (161032); Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway (161030); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Neuronal System Pathway (106513); Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway (106534)
ncbi summary :
This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]
uniprot summary :
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.