CNGA1 Antibody | MyBioSource MBS851859 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CNGA1 Antibody

catalog :

MBS851859

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS851859

products type :

Antibody

products full name :

CNGA1 Antibody

products short name :

CNGA1

products name syn :

cGMP-gated cation channel alpha 1; CNCG; CNCG1; CNG channel alpha 1; CNG-1; CNG1; Cyclic nucleotide gated channel alpha 1; Cyclic nucleotide gated channel; photoreceptor; Cyclic-nucleotide-gated cation channel 1; Rod photoreceptor cGMP-gated channel alpha subunit

other names :

cGMP-gated cation channel alpha-1 isoform 2; cGMP-gated cation channel alpha-1; cGMP-gated cation channel alpha-1; CNG channel alpha-1; interleukin-1 homologue; cyclic nucleotide-gated channel alpha-1; cyclic nucleotide-gated cation channel 1; cyclic nucleotide-gated channel, photoreceptor; rod photoreceptor cGMP-gated channel subunit alpha; cyclic nucleotide gated channel alpha 1; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha

products gene name :

CNGA1

other gene names :

CNGA1; CNGA1; CNCG; CNG1; RP49; CNCG1; CNG-1; RCNC1; RCNCa; RCNCalpha; CNCG; CNCG1; CNG channel alpha-1; CNG-1; CNG1

uniprot entry name :

CNGA1_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

690

specificity :

CNGA1 antibody detects endogenous levels of total CNGA1 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB: 1:500~1:1000, ELISA: 1:40000

other info1 :

Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from internal of human CNGA1. Pathway: Channel

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Pittler S.J., J. Biol. Chem. 267:6257-6262(1992). Dhallan R.S., J. Neurosci. 12:3248-3256(1992). Ota T., Nat. Genet. 36:40-45(2004). ---------------------------------------------------------------------------------------------------------------------------------------

ncbi gi num :

71143141

ncbi acc num :

NP_000078.2

ncbi gb acc num :

NM_000087.3

uniprot acc num :

P29973

ncbi mol weight :

86,900 Da

ncbi pathways :

Activation Of The Phototransduction Cascade Pathway (833794); Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway (833795); Phototransduction Pathway (149806); Phototransduction Pathway (148660); Signal Transduction Pathway (477114); The Phototransduction Cascade Pathway (833793); Visual Phototransduction Pathway (771584); Visual Signal Transduction: Rods Pathway (138074)

ncbi summary :

The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

uniprot summary :

CNGA1: a cyclic nucleotide-gated cation channel of rod cells in the retina. Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. Activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. CNG ion channels exist in the retinal, olfactory and cochlear sensory neurons. Protein type: Membrane protein, multi-pass; Channel, cation; Membrane protein, integral. Chromosomal Location of Human Ortholog: 4p12. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: protein binding; voltage-gated potassium channel activity; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; cGMP binding. Biological Process: rhodopsin mediated signaling; phototransduction, visible light; regulation of membrane potential; regulation of rhodopsin mediated signaling; visual perception; transport. Disease: Retinitis Pigmentosa 49; Retinitis Pigmentosa

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage