PAK2 (Phospho-Ser197) Antibody | MyBioSource MBS851825 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PAK2 (Phospho-Ser197) Antibody

catalog :

MBS851825

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS851825

products type :

Antibody

products full name :

PAK2 (Phospho-Ser197) Antibody

products short name :

PAK2

products name syn :

EC 2.7.11.1; gamma-PAK; kinase PAK2; P21-activated kinase 2; p21-activated kinase 2; p21-activated protein kinase I; PAK 2; PAK-2; PAK65; PAKI; S6/H4 kinase

other names :

serine/threonine-protein kinase PAK 2; Serine/threonine-protein kinase PAK 2; serine/threonine-protein kinase PAK 2; p58; PAK-2; gamma-PAK; S6/H4 kinase; p21-activated kinase 2; p21 (CDKN1A)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2; p58Cleaved into the following 2 chains:PAK-2p27; p27; PAK-2p34; p34Alternative name(s):C-t-PAK2

products gene name :

PAK2

other gene names :

PAK2; PAK2; PAK65; PAKgamma; PAK-2; p27; p34

uniprot entry name :

PAK2_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

524

specificity :

PAK2 (Phospho-Ser197) antibody detects endogenous levels of PAK2 only when phosphorylated at serine 197.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1mg/ml

storage stability :

Store at -20 degree C for 1 year

tested application :

Immunohistochemistry (IHC), ELISA (EIA)

app notes :

IHC: 1:50~1:100, ELISA: 1:1000

other info1 :

Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 92%, Positives = 100%); Rat (Identities = 92%, Positives = 100%)

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human PAK2 around the phosphorylation site of serine 197 (T-R-SP-V-I). All Sites: Human: Ser197; Mouse: Ser197; Rat: Ser197. Pathway: Phospho-specific

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Martin G.A., EMBO J. 14:1970-1978(1995). The MGC Project Team; Genome Res. 14:2121-2127(2004). Olsen J.V., Cell 127:635-648(2006). ----------------------------------------------------------------------------

ncbi gi num :

32483399

ncbi acc num :

NP_002568.2

ncbi gb acc num :

NM_002577.4

uniprot acc num :

Q13177

ncbi mol weight :

58,043 Da

ncbi pathways :

Activation Of Rac Pathway (119530); Adaptive Immune System Pathway (366160); Apoptosis Pathway (105648); Apoptotic Execution Phase Pathway (105677); Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); C-MYC Pathway (169344); CD28 Co-stimulation Pathway (119553); CD28 Dependent Vav1 Pathway (119555)

ncbi summary :

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]

uniprot summary :

PAK2: a protein kinase of the STE20 family. Critical effector linking RhoGTPases to cytoskeleton reorganization and nuclear signaling. Activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. Protein type: Protein kinase, STE; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; PAKA subfamily. Chromosomal Location of Human Ortholog: 3q29. Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; plasma membrane; cytosol. Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; protein tyrosine kinase activator activity; protein kinase binding; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity. Biological Process: axon guidance; viral reproduction; apoptosis; protein amino acid autophosphorylation; signal transduction; T cell receptor signaling pathway; protein amino acid phosphorylation; regulation of defense response to virus by virus; regulation of apoptosis; positive regulation of peptidyl-tyrosine phosphorylation; peptidyl-serine phosphorylation; regulation of growth; T cell costimulation; negative regulation of protein kinase activity; innate immune response; mitotic cell cycle; vascular endothelial growth factor receptor signaling pathway; phosphorylation; cell structure disassembly during apoptosis; negative regulation of apoptosis

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage