catalog number :
MBS851785
products full name :
C1S Antibody
products short name :
[C1S]
products name syn :
[28S ribosomal protein S7,mitochondrial; S7mt; MRP-S7; bMRP27a; bMRP-27a]
other names :
[complement C1s subcomponent isoform 2; Complement C1s subcomponent; complement C1s subcomponent; complement C1s; C1 esterase; Complement component 1 subcomponent s]
products gene name :
[C1S]
other gene names :
[C1S; C1S; EDSPD2]
specificity :
C1S antibody detects endogenous levels of total C1S protein.
purity :
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at-20 degree C for 1 year.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
app notes :
WB: 1:500~1:1000. IHC: 1:50~1:100. ELISA: 1:40000
image1 heading :
Testing Data
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human C1S.
products categories :
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
products references :
McKinnon C.M., Eur. J. Biochem. 169:547-553(1987). Tosi M., Biochemistry 26:8516-8524(1987). Kusumoto H., Proc. Natl. Acad. Sci. U.S.A. 85:7307-7311(1988).
ncbi acc num :
NP_001333779.1
ncbi gb acc num :
NM_001346850.1
ncbi mol weight :
76,684 Da
ncbi pathways :
Classical Antibody-mediated Complement Activation Pathway (1269246); Complement Activation Pathway (198823); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (1269241); Creation Of C4 And C2 Activators Pathway (1269243); Immune System Pathway (1269170); Initial Triggering Of Complement Pathway (1269242); Innate Immune System Pathway (1269203)
ncbi summary :
This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009]
uniprot summary :
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.