catalog number :
MBS8517575
products full name :
SRD5A2 Antibody
products short name :
[SRD5A2]
products name syn :
[3 oxo 5 alpha steroid 4 dehydrogenase 2; 3 –oxo-5- alpha-steroid;4-dehydrogenase 2; 5 alpha SR2; 5 alpha-SR2; 5ART2; e II 5 alpha reductase; EC; MGC138457 ; Micropenis, included; S5A2_HUMAN; S5AR 2; SR type 2; SRD5A2; Steroid 5 alpha reductase 2; Steroid 5- alpha-reductase 2; Steroid-5- alpha-reductase , alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4- dehydrogenase alpha 2); Type II 5 alpha reductase
]
other names :
[3-oxo-5-alpha-steroid 4-dehydrogenase 2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2; steroid 5 alpha-reductase 2; 5 alpha-SR2; SR type 2; Steroid 5-alpha-reductase 2; S5AR 2; Type II 5-alpha reductase]
products gene name :
[SRD5A2]
other gene names :
[SRD5A2; SRD5A2; S5AR 2]
specificity :
SRD5A2 Antibody detects endogenous levels of total SRD5A2.
purity :
The antiserum was purified by peptide affinity chromatography using Sulfo link TM Coupling Resin (Thermo Fisher Scientific).
form :
Rabbit IgG in phosphate buffered saline, pH 7.4 150 mM NaCI, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20°C/ 1 year.
tested application :
Western Blot (WB), ELISA (peptide)
app notes :
Western Blot (WB) 1:1000-3000. ELISA (peptide) 1:20000-1:40000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: A synthesized peptide derived from human SRD5A2.
ncbi acc num :
NP_000339.2
ncbi gb acc num :
NM_000348.3
ncbi pathways :
Androgen Biosynthesis Pathway (1270050); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Metabolism Of Steroid Hormones Pathway (1270046); Prostate Cancer Pathway (83111); Prostate Cancer Pathway (523); Steroid Hormone Biosynthesis Pathway (82940); Steroid Hormone Biosynthesis Pathway (301); Allopregnanolone Biosynthesis Pathway (1108771); Allopregnanolone Biosynthesis Pathway (1108836)
ncbi summary :
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008]
uniprot summary :
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.