catalog number :
MBS8516924
products full name :
Phospho-nrf2 (S40) Antibody
products short name :
[nrf2]
other names :
[nuclear factor erythroid 2-related factor 2 isoform 2; Nuclear factor erythroid 2-related factor 2; nuclear factor erythroid 2-related factor 2; nuclear factor, erythroid 2 like 2; HEBP1; Nuclear factor, erythroid derived 2, like 2]
products gene name :
[nrf2]
other gene names :
[NFE2L2; NFE2L2; NRF2; HEBP1; IMDDHH; NRF2; NF-E2-related factor 2; NFE2-related factor 2]
image1 heading :
Western Blot (WB)
ncbi acc num :
NP_001138884.1
ncbi gb acc num :
NM_001145412.3
ncbi mol weight :
65,356 Da
ncbi pathways :
AhR Pathway (755436); Keap1-Nrf2 Pathway (198777); Oxidative Stress Pathway (198916); Protein Processing In Endoplasmic Reticulum Pathway (167325); Protein Processing In Endoplasmic Reticulum Pathway (167190); Selenium Metabolism And Selenoproteins Pathway (198846)
ncbi summary :
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]
uniprot summary :
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.