EPB41 (Phospho-Tyr660/418) Antibody | MyBioSource MBS851681 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

EPB41 (Phospho-Tyr660/418) Antibody

catalog :

MBS851681

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS851681

products type :

Antibody

products full name :

EPB41 (Phospho-Tyr660/418) Antibody

products short name :

EPB41

products name syn :

4.1R; 41; band 4.1; E41P; EPB4.1; erythrocyte membrane protein band 4.1; P4.1; protein 4.1

other names :

protein 4.1 isoform 1; Protein 4.1; protein 4.1; P4.1; EPB4.1; band 4.1; elliptocytosis 1, RH-linked; erythrocyte surface protein band 4.1; erythrocyte membrane protein band 4.1; 4.1R; Band 4.1; EPB4.1

products gene name :

EPB41

other gene names :

EPB41; EPB41; HE; EL1; 4.1R; E41P; P4.1

uniprot entry name :

41_HUMAN

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

864

specificity :

EPB41 (Phospho-Tyr660/418) antibody detects endogenous levels of EPB41 only when phosphorylated at tyrosine 660/418.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation s

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB: 1:500~1:1000, ELISA: 1:1000

other info1 :

Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%)

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human EPB41 around the phosphorylation site of tyrosine 660/418 (N-I-YP-I-R). All Sites: Human: Tyr660; Mouse: Tyr654. Pathway: Phospho-specific

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Conboy J.G., Proc. Natl. Acad. Sci. U.S.A. 83:9512-9516(1986). Tang T.K., Adv. Exp. Med. Biol. 241:81-95(1988). Tang T.K., Proc. Natl. Acad. Sci. U.S.A. 85:3713-3717(1988). ----------------------------------------------------------------------------

ncbi gi num :

260436831

ncbi acc num :

NP_001159477.1

ncbi gb acc num :

NM_001166005.1

uniprot acc num :

P11171

ncbi mol weight :

81,235 Da

ncbi pathways :

Syndecan-2-mediated Signaling Events Pathway (138031); Tight Junction Pathway (83071); Tight Junction Pathway (482)

ncbi summary :

The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]

uniprot summary :

EPB41: Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Defects in EPB41 are the cause of elliptocytosis type 1 (EL1). EL1 is a Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant, hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP). HPP is an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells. 7 isoforms of the human protein are produced by alternative splicing. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 1p33-p32. Cellular Component: spectrin; cortical cytoskeleton; Golgi apparatus; protein complex; extrinsic to membrane; intracellular membrane-bound organelle; plasma membrane; nucleus. Molecular Function: calmodulin binding; protein binding; spectrin binding; structural constituent of cytoskeleton; actin binding; phosphatidylinositol binding. Biological Process: positive regulation of protein binding; blood circulation; cortical actin cytoskeleton organization and biogenesis; actin cytoskeleton organization and biogenesis. Disease: Elliptocytosis 1; Pyropoikilocytosis, Hereditary

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage