catalog number :
MBS8516620
products full name :
SLC1A4 Antibody
products short name :
[SLC1A4]
products name syn :
[ASCT1; SATT]
other names :
[neutral amino acid transporter A isoform 2; Neutral amino acid transporter A; neutral amino acid transporter A; solute carrier family 1 member 4; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; SATT; Solute carrier family 1 member 4]
products gene name :
[SLC1A4]
other gene names :
[SLC1A4; SLC1A4; SATT; ASCT1; SPATCCM; ASCT1; SATT; ASCT-1]
reactivity :
Human, Mouse, Rat
specificity :
SLC1A4 Antibody detects endogenous levels of total SLC1A4
purity :
Immunogen affinity purified
form :
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20°C. Stable for 12 months from date of receipt.
storage stability :
Store at-20°C for 1 year.
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500-1:2000. IHC: 1:50-1:200
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: A synthetic peptide of human SLC1A4
products description :
SLC1A4, also known as ASCT1, is a neutral amino acid transporter. Its other name, ASCT1, was given because it mediates obligatory exchange of alanine, serine, cysteine, and threonine (1). SLC1A4 mediates the efflux of glutamate from the neuron into the synaptic junction via calcium-independent release, as well as mediating the efflux of L-serine from glial cells and its uptake by neurons (2). SLC1A4-mediated transport is shown to involve a symmetrical potassium-independent electroneutral exchange of neutral amino acids and sodium, such that the current activated during transport is carried only by chloride ions (3).
ncbi acc num :
NP_001180422.1
ncbi gb acc num :
NM_001193493.1
ncbi pathways :
Amino Acid Transport Across The Plasma Membrane Pathway (1269916); SLC-mediated Transmembrane Transport Pathway (1269907); Transmembrane Transport Of Small Molecules Pathway (1269903); Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway (1269908)
ncbi summary :
The protein encoded by this gene is a sodium-dependent neutral amino acid transporter for alanine, serine, cysteine, and threonine. Defects in this gene have been associated with developmental delay, microcephaly, and intellectual disability. [provided by RefSeq, Jan 2017]
uniprot summary :
Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence.