catalog number :
MBS851571
products full name :
IKZF4 Antibody
products short name :
[IKZF4]
products name syn :
[Zinc finger protein Eos, Ikaros family zinc finger protein 4; IKZF4; KIAA1782; ZNFN1A4]
other names :
[zinc finger protein Eos isoform a; Zinc finger protein Eos; zinc finger protein Eos; IKAROS family zinc finger 4; Ikaros family zinc finger protein 4]
products gene name :
[IKZF4]
other gene names :
[IKZF4; IKZF4; EOS; ZNFN1A4; KIAA1782; ZNFN1A4]
reactivity :
Human, Mouse, Rat
specificity :
IKZF4 antibody detects endogenous levels of total IKZF4 protein.
purity :
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at-20 degree C for 1 year.
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
WB: 1:500~1:1000. ELISA: 1:40000
image1 heading :
Testing Data #2
other info1 :
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human IKZF4.
products categories :
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
products references :
Ohara O., DNA Res. 8:85-95(2001). Schupp I., BMC Genomics 8:399-399(2007). Georgopoulos K., J. Biol. Chem. 277:27697-27705(2002).
ncbi acc num :
NP_071910.3
ncbi gb acc num :
NM_022465.3
ncbi mol weight :
59,671 Da
ncbi summary :
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
uniprot summary :
DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 ().