product summary
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company name :
MyBioSource
product type :
antibody
product name :
PTAFR Antibody
catalog :
MBS851559
quantity :
0.1 mg
price :
215 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
ELISA, immunocytochemistry, enzyme immunoassay
more info or order :
product information
catalog number :
MBS851559
products type :
Antibody
products full name :
PTAFR Antibody
products short name :
PTAFR
products name syn :
PAF-R; Platelet-activating factor receptor
other names :
platelet-activating factor receptor; Platelet-activating factor receptor; platelet-activating factor receptor; PAF-R; platelet-activating factor receptor
products gene name :
PTAFR
other gene names :
PTAFR; PTAFR; PAFR; PAFR; PAF-R; PAFr
uniprot entry name :
PTAFR_HUMAN
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
342
specificity :
PTAFR antibody detects endogenous levels of total PTAFR protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20 degree C for 1 year
tested application :
Immunofluorescence (IF), ELISA (EIA)
app notes :
IF: 1:100~1:500, ELISA: 1:10000
other info1 :
Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 85%, Positives = 85%); Rat (Identities = 85%, Positives = 85%)
other info2 :
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human PTAFR. Pathway: GPCR
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Ye R.D., Biochem. Biophys. Res. Commun. 180:105-111(1991). Nakamura M., J. Biol. Chem. 266:20400-20405(1991). Kunz D., J. Biol. Chem. 267:9101-9106(1992).
ncbi gi num :
4506241
ncbi acc num :
NP_000943.1
ncbi gb acc num :
NM_000952.4
uniprot acc num :
P25105
ncbi mol weight :
39,203 Da
ncbi pathways :
Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine Signaling In Immune System Pathway (366171); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Immune System Pathway (106386)
ncbi summary :
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
uniprot summary :
PTAFR: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Protein type: Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR. Chromosomal Location of Human Ortholog: 1p35-p34.3. Cellular Component: nucleoplasm; membrane; intracellular membrane-bound organelle; integral to plasma membrane; integral to membrane; plasma membrane. Molecular Function: G-protein coupled receptor activity; platelet activating factor receptor activity; purinergic nucleotide receptor activity, G-protein coupled; lipopolysaccharide binding; phospholipid binding; lipopolysaccharide receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; phosphoinositide-mediated signaling; inositol trisphosphate biosynthetic process; cytokine and chemokine mediated signaling pathway; lipopolysaccharide-mediated signaling pathway; cytokine production; immune response; inflammatory response; chemotaxis
size1 :
0.1 mg
price1 :
215 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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