antibody

Lubricin/PRG4 Antibody

MBS851542

0.1 mg

290 USD

polyclonal

rabbit

nonconjugated

human, rat

Antibody

Lubricin/PRG4 Antibody

Lubricin/PRG4

Homo sapiens proteoglycan 4 (PRG4), transcript variant A, mRNA; Proteoglycan 4; proteoglycan 4; lubricin; superficial zone proteoglycan; megakaryocyte stimulating factor; megakaryocyte-stimulating factor; articular superficial zone protein; bG174L6.2 (MSF: megakaryocyte stimulating factor ); proteoglycan 4; Lubricin; Megakaryocyte-stimulating factor; Superficial zone proteoglycanCleaved into the following chain:Proteoglycan 4 C-terminal part

PRG4; PRG4; MSF; SZP; CACP; HAPO; JCAP; bG174L6.2; MSF; SZP

PRG4_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

5059

Lyophilized anti-PRG4 antibody purified by peptide affinity column containing 2% BSA and 0.02% NaN3

100ug/200ul

Western Blot (WB)

Peptide ELISA titer: 1:10,000-1:80,000. Western blot analysis: 1:200-1,000. Optimal dilutions/concentrations should be determined by the end user.

Source Note: Rabbit polyclonal PRG4 (1) antibody was raised against a peptide corresponding to the N terminus residues of human PRG4. Reactivity Note: Not yet tested in other species.

Dilution Instruction and Storage: Already reconstiuted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconsitution. Avoid repeated freeze/defrost cycles.

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

(1) Chen,Z., Liu,F., Ren,Q.,et al. Hemangiopoietin promotes endothelial cell proliferation through PI-3K/Akt pathway. Cell. Physiol. Biochem. 22 (1-4), 307-314 (2008)

189163478

NP_005798.2

NM_005807

146,468 Da

The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PRG4: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Defects in PRG4 are the cause of camptodactyly- arthropathy-coxa vara-pericarditis syndrome (CACP); also known as Jacobs syndrome. CACP is an autosomal recessive disorder. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure associated with noninflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1q25-q31. Cellular Component: extracellular space. Molecular Function: scavenger receptor activity; polysaccharide binding. Biological Process: receptor-mediated endocytosis; cell proliferation; negative regulation of interleukin-6 biosynthetic process; immune response; regulation of cell proliferation. Disease: Camptodactyly-arthropathy-coxa Vara-pericarditis Syndrome

0.1 mg

290 USD