antibody

G1/S-specific cyclin-D1 Antibody

MBS851324

0.1 mg

355 USD

monoclonal

mouse

nonconjugated

western blot, ELISA, enzyme immunoassay

Antibody

G1/S-specific cyclin-D1 Antibody

G1/S-specific cyclin-D1

G1/S-specific cyclin-D1; G1/S-specific cyclin-D1; G1/S-specific cyclin-D1; BCL-1 oncogene; PRAD1 oncogene; B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; cyclin D1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene

CCND1; CCND1; BCL1; PRAD1; U21B31; D11S287E; BCL1; PRAD1; BCL-1

CCND1_HUMAN

Monoclonal

IgG2b

Mouse

295

Anti-G1/S-specific cyclin-D1 recognizes recombinant protein G1/S-specific cyclin-D1.

Each vial contains 100 ug IgG in 100 ul of citrate-tris-HCl buffer pH7.0 with 0.02% Proclin 300.

The antibody may be stored at -20 degree C for one year in its original formulation. Additionally, antibody may be stored at 2 degree C to 8 degree C for up to 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles of the diluted antibody.

ELISA (EIA), Western Blot (WB-Re)

Source Note: Purified mouse monoclonal antibody generated using E Coli expressed recombinant protein G1/S-specific cyclin-D1 as immunogen.

Immunogen: Recombinant protein corresponding to full length G1/S-specific cyclin-D1.

Plant antibody

16950655

NP_444284.1

NM_053056.2

33,729 Da

AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!ATF-2 Transcription Factor Network Pathway 138006!!Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Androgen Receptor Signaling Pathway 198806!!Bladder Cancer Pathway 83115!!Bladder Cancer Pathway 527!!C-MYB Transcription Factor Network Pathway 138073!!Cell Cycle Pathway 530733

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]

0.1 mg

355 USD