CNR1 Antibody | MyBioSource MBS851303 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CNR1 Antibody

catalog :

MBS851303

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS851303

products type :

Antibody

products full name :

CNR1 Antibody

products short name :

CNR1

products name syn :

CANN6; cannabinoid receptor 1; CB-R; CB1; CB1R; CNR

other names :

cannabinoid receptor 1 isoform a; Cannabinoid receptor 1; cannabinoid receptor 1; central cannabinoid receptor; cannabinoid receptor 1 (brain); CANN6

products gene name :

CNR1

other gene names :

CNR1; CNR1; CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5; CNR; CB-R; CB1

uniprot entry name :

CNR1_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

472

specificity :

CNR1 antibody detects endogenous levels of total CNR1 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:1000

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from internal of human CNR1. Pathway: GPCR

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Gerard C., Nucleic Acids Res. 18:7142-7142(1990). Gerard C., Biochem. J. 279:129-134(1991). Shire D., J. Biol. Chem. 270:3726-3731(1995).

ncbi gi num :

237681067

ncbi acc num :

NP_001153698.1

ncbi gb acc num :

NM_001160226.1

uniprot acc num :

P21554

ncbi mol weight :

49,060 Da

ncbi pathways :

BDNF Signaling Pathway (712093); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); N-cadherin Signaling Events Pathway (137919); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Rap1 Signaling Pathway (868086)

ncbi summary :

This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]

uniprot summary :

CNR1: Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR. Chromosomal Location of Human Ortholog: 6q14-q15. Cellular Component: growth cone; intracellular membrane-bound organelle; integral to plasma membrane; axon; plasma membrane. Molecular Function: cannabinoid receptor activity; drug binding. Biological Process: response to nicotine; maternal process involved in pregnancy; regulation of synaptic transmission, glutamatergic; negative regulation of fatty acid beta-oxidation; positive regulation of apoptosis; response to morphine; positive regulation of acute inflammatory response to antigenic stimulus; response to lipopolysaccharide; sensory perception of pain; glucose homeostasis; negative regulation of blood pressure; negative regulation of dopamine secretion; response to nutrient; aging; negative regulation of mast cell activation; negative regulation of nitric-oxide synthase activity; axonal fasciculation; negative regulation of action potential; response to cocaine; memory; regulation of synaptic transmission, GABAergic; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; response to ethanol; positive regulation of fever; spermatogenesis; regulation of insulin secretion; positive regulation of blood pressure

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage