product summary
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company name :
MyBioSource
product type :
other
product name :
Cleaved-caspase 3 antibody
catalog :
MBS8512521
quantity :
0.1 mg
price :
290 USD
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS8512521 image 1
145$
image 2 :
MyBioSource MBS8512521 image 2
product information
catalog number :
MBS8512521
products type :
Antibody
products full name :
Cleaved-caspase 3 antibody
products short name :
[caspase 3]
products name syn :
[Apopain precursor; CPP-32; CPP32; Caspase-3; Cysteine protease CPP32; ICE3; SCA-1; SREBP cleavage activity 1; Yama protein, p17]
other names :
[caspase-3 isoform a preproprotein; Caspase-3; caspase-3; caspase 3; Apopain; Cysteine protease CPP32; CPP-32]
products gene name :
[CASP-3]
other gene names :
[CASP3; CASP3; CPP32; SCA-1; CPP32B; CPP32; CASP-3; CPP-32; SCA-1]
reactivity :
Human, Mouse, Rat
sequence length :
277
specificity :
Caspase 3 (p17, Cleaved-Asp175) Antibody detects endogenous levels of fragment of activated Caspase 3 resulting from cleavage adjacent to Asp175.
purity :
Immunogen affinity purified
form :
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20°C for 1 year. Stable for 12 months from date of receipt.
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500-1:2000. IHC: 1:50-1:200
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemisry (IHC)
other info1 :
Immunogen: The antiserum was produced against synthesized peptide derived from human Caspase 3.
products description :
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.
ncbi gi num :
14790119
ncbi acc num :
NP_004337.2
ncbi gb acc num :
NM_004346.3
uniprot acc num :
P42574
ncbi mol weight :
17kDa
ncbi pathways :
AGE/RAGE Pathway (698754); Activation Of DNA Fragmentation Factor Pathway (105683); Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway (105672); Alpha6-Beta4 Integrin Signaling Pathway (198807); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099)
ncbi summary :
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
uniprot summary :
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
size1 :
0.1 mg
price1 :
290 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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