catalog number :
MBS8512093
products full name :
HSP70 Antibody
products short name :
[HSP70]
products name syn :
[In cooperation with other chaperones; Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes throu???????????????]
other names :
[heat shock 70 kDa protein 1B; heat shock protein family A (Hsp70) member 1B]
products gene name :
[HSP70]
other gene names :
[HSPA1B; HSP70-2; HSP70.2; HSP70-1B]
reactivity :
Human, Mouse, Rat
specificity :
HSP70 Antibody detects endogenous levels of total HSP70
purity :
Immunogen affinity purified
form :
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at-20 degree C for 1 year
tested application :
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
WB: 1:500-1:2000. IHC: 1:50-1:200. IF: 1:100-1:500
other info1 :
Immunogen: A synthesized peptide derived from human HSP70
products description :
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins.
ncbi pathways :
AUF1 (hnRNP D0) Destabilizes MRNA Pathway (187212); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Apoptosis Modulation By HSP70 Pathway (198877); Attenuation Phase Pathway (1127556); Cellular Response To Heat Stress Pathway (1127553); Cellular Responses To Stress Pathway (645258); Direct P53 Effectors Pathway (137939); Disease Pathway (530764); Endocytosis Pathway (102279)
ncbi summary :
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]