other

PGC1 alpha antibody

MBS8512025

0.1 mg

290 USD

Antibody

PGC1 alpha antibody

[PGC1 alpha]

[PGC 1 alpha antibody; PGC 1v antibody; PGC-1-alpha antibody; PGC1 antibody; PGC1(alpha) antibody; PGC1A antibody; PGC1v antibody; PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6 antibody; PPAR gamma coactivator 1 alpha antibody]

[peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 1; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PPARG coactivator 1 alpha; Ligand effect modulator 6]

[PGC1 alpha]

[PPARGC1A; PPARGC1A; LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1alpha; PGC-1(alpha); LEM6; PGC1; PGC1A; PPARGC1; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha]

Human, Mouse, Rat

803

PGC1 alpha antibody detects endogenous levels of total PGC1 alpha

Immunogen affinity purified

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20°C. Stable for 12 months from date of receipt.

Store at-20 degree C for 1 year

Western Blot (WB)

WB: 1:500-1:2000

Immunogen: A synthesized peptide derived from human PGC1 alpha

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis.

1064788214

NP_001317680.1

NM_001330751.1

Q9UBK2

91 kDa

AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); ATF-2 Transcription Factor Network Pathway (138006); Activation Of PPARGC1A (PGC-1alpha) By Phosphorylation Pathway (1268840); Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Adipogenesis Pathway (198832); Apelin Signaling Pathway (1492886); BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway (1269872); Circadian Clock Pathway (1269871)

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.

0.1 mg

290 USD