Retinoic Acid Receptor alpha (Phospho-Ser77) Antibody | MyBioSource MBS851138 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Retinoic Acid Receptor alpha (Phospho-Ser77) Antibody

catalog :

MBS851138

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS851138

products type :

Antibody

products full name :

Retinoic Acid Receptor alpha (Phospho-Ser77) Antibody

products short name :

Retinoic Acid Receptor alpha

products name syn :

Retinoic Acid Receptor a (Phospho-Ser77) Antibody; NR1B1; RAR-alpha; Retinoic acid receptor alpha; retinoic acid receptor; alpha; RRA

other names :

retinoic acid receptor alpha isoform 1; Retinoic acid receptor alpha; retinoic acid receptor alpha; RAR-alpha; retinoic acid receptor, alpha polypeptide; nuclear receptor subfamily 1 group B member 1; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; retinoic acid receptor, alpha; Nuclear receptor subfamily 1 group B member 1

other gene names :

RARA; RARA; RAR; NR1B1; NR1B1; RAR-alpha

uniprot entry name :

RARA_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

462

specificity :

Retinoic Acid Receptor alpha (Phospho-Ser77) antibody detects endogenous levels of Retinoic Acid Receptor alpha only when phosphorylated at serine 77.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody againstnon-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation s

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:5000

other info1 :

Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Retinoic Acid Receptor alpha around the phosphorylation site of serine 77 (P-P-SP-P-P). All Sites: Human: Ser77; Mouse: Ser77; Rat: Ser74. Pathway: Phospho-specific

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Giguere V., Nature 330:624-629(1987). Chen Z., Proc. Natl. Acad. Sci. U.S.A. 91:1178-1182(1994). Hjalt T.A.H., Mamm. Genome 10:528-529(1999).

ncbi gi num :

4506419

ncbi acc num :

NP_000955.1

ncbi gb acc num :

NM_000964.3

uniprot acc num :

P10276

ncbi mol weight :

39,700 Da

ncbi pathways :

Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adipogenesis Pathway (198832); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); IL-3 Signaling Pathway (198881); Integrated Pancreatic Cancer Pathway (711360); Nuclear Receptor Transcription Pathway (105979); Nuclear Receptors Pathway (198848); Nuclear Receptors In Lipid Metabolism And Toxicity Pathway (198887)

ncbi summary :

This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]

uniprot summary :

RARA: is a receptor for retinoic acid, a potent mammalian morphogen and teratogen that has profound effects on vertebrate development. RARA is a member of the nuclear receptor superfamily. Controls cell function by directly regulating gene expression. Its phosphorylation is crucial for transcriptional activity. Aberrations involving RARA may be a cause of acute promyelocytic leukemia. Two splice-variant isoforms have been described. Protein type: Transcription factor; DNA-binding; Oncoprotein; Nuclear receptor. Chromosomal Location of Human Ortholog: 17q21. Cellular Component: nucleoplasm; cell surface; cell soma; perinuclear region of cytoplasm; cytoplasm; nuclear chromatin; dendrite; nucleus; actin cytoskeleton. Molecular Function: protein kinase B binding; protein domain specific binding; retinoic acid binding; zinc ion binding; chromatin DNA binding; transcription coactivator activity; translation repressor activity, nucleic acid binding; phosphoinositide 3-kinase regulator activity; drug binding; alpha-actinin binding; transcription factor binding; protein binding; enzyme binding; protein heterodimerization activity; protein kinase A binding; steroid hormone receptor activity; mRNA 5 -UTR binding; retinoic acid receptor activity; transcription factor activity; transcription corepressor activity; receptor binding. Biological Process: prostate gland development; negative regulation of translational initiation; regulation of myelination; estrogen receptor signaling pathway; glandular epithelial cell development; positive regulation of transcription, DNA-dependent; regulation of synaptic plasticity; female pregnancy; regulation of phosphoinositide 3-kinase activity; protein amino acid phosphorylation; response to vitamin A; germ cell development; Sertoli cell fate commitment; positive regulation of T-helper 2 cell differentiation; positive regulation of cell cycle; positive regulation of phosphoinositide 3-kinase cascade; response to ethanol; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; limb development; retinoic acid receptor signaling pathway; ventricular cardiac muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter; signal transduction; response to estradiol stimulus; negative regulation of granulocyte differentiation; positive regulation of interleukin-4 production; negative regulation of cell proliferation; ureteric bud development; negative regulation of interferon-gamma production; positive regulation of cell proliferation; positive regulation of interleukin-13 production; transmembrane transport; positive regulation of interleukin-5 production; transcription initiation from RNA polymerase II promoter; response to retinoic acid; multicellular organism growth; negative regulation of tumor necrosis factor production; positive regulation of binding; liver development; embryonic camera-type eye development; positive regulation of protein kinase B signaling cascade; response to cytokine stimulus; neural tube closure; gene expression; spermatogenesis; positive regulation of neuron differentiation; apoptotic cell clearance. Disease: Acute Promyelocytic Leukemia

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage