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Phospho-Survivin (Thr117) Antibody

MBS8511201

0.1 mg

290 USD

Antibody

Phospho-Survivin (Thr117) Antibody

[Survivin]

[API4; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; BIRC5; Baculoviral IAP repeat-containing protein 5; IAP4; TIAP]

[baculoviral IAP repeat-containing protein 5 isoform 2; Baculoviral IAP repeat-containing protein 5; baculoviral IAP repeat-containing protein 5; baculoviral IAP repeat containing 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin]

[BIRC5; BIRC5; API4; EPR-1; API4; IAP4]

Human, Mouse, Rat

137

Phospho-Survivin (Thr117) Antibody detects endogenous levels of Survivin only when phosphorylated at Threonine 117

Immunogen affinity purified

Rabbit IgG in phosphate buffered saline, pH 7.4 150mM NaCI, 0.02% sodium azide and 50% glycerol.

Store at -20°C. Stable for 12 months from date of receipt.

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

WB: 1:500-1:2000. IHC: 1:50-1:200. IF/ICC: 1:100-1:500

Western Blot (WB)

Immunogen: A synthesized peptide derived from human Survivin around the phosphorylation site of Threonine 117

Survivin is an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia.

59859880

NP_001012270.1

NM_001012270.1

O15392

16kDa

Apoptosis Pathway (198797); Apoptosis Modulation And Signaling Pathway (198822); Aurora A Signaling Pathway (137925); Aurora B Signaling Pathway (138080); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Colorectal Cancer Pathway (83106); Colorectal Cancer Pathway (518); FOXM1 Transcription Factor Network Pathway (137935); Hepatitis B Pathway (694606)

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797).

0.1 mg

290 USD