antibody

LOXL1 Antibody

MBS851103

0.1 mg

290 USD

polyclonal

rabbit

nonconjugated

western blot, immunohistochemistry

Antibody

LOXL1 Antibody

LOXL1

Homo sapiens lysyl oxidase-like 1 (LOXL1), mRNA; Lysyl oxidase homolog 1; lysyl oxidase homolog 1; lysyl oxidase-like protein 1; lysyl oxidase-like 1; Lysyl oxidase-like protein 1; LOL

LOXL1

LOXL1; LOXL1; LOL; LOXL; LOXL; LOL

LOXL1_HUMAN

Polyclonal

Rabbit

Human

2361

Lyophilized anti-LOXL1 antibody purified by peptide affinity column containing 1% BSA and 0.02% NaN3

100ug/200ul

Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.

Western Blot (WB), Immunohistochemistry (IHC)

Peptide ELISA titer: 1:10,000-1:40,000. Western blot analysis: 1:200-500. Immunohistochemistry: 1:100-500. Optimal dilutions/concentrations should be determined by the end user.

Source Note: Rabbit polyclonal LOXL1 (1) antibody was raised against a 16 amino acid peptide from near the N terminal residues of human LOXL1 protein. Reactivity Note: Not yet tested in other species.

Pathway: lysyl oxidase-like 1

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

67782345

NP_005567.2

NM_005576

63,110 Da

Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Collagen Formation Pathway (645288); Crosslinking Of Collagen Fibrils Pathway (730308); Elastic Fibre Formation Pathway (730310); Extracellular Matrix Organization Pathway (576262)

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

LOXL1: Active on elastin and collagen substrates. Genetic variations in LOXL1 are a cause of susceptibility to exfoliation syndrome (XFS); also called exfoliation glaucoma (XFG). XFS is a disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues. Susceptibility to exfoliation syndrome is conferred by a risk haplotype that includes two LOXL1 coding non-synonymous SNPs (Arg141Leu and Gly153Asp) and one intronic SNP. Arg141Leu and Gly153Asp are sufficient to confer disease susceptibility in some populations. Belongs to the lysyl oxidase family. Protein type: Secreted, signal peptide; Oxidoreductase; EC 1.4.3.-; Secreted; Extracellular matrix. Chromosomal Location of Human Ortholog: 15q22. Cellular Component: extracellular matrix; extracellular space; acrosome; extracellular region; basement membrane. Molecular Function: copper ion binding; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Biological Process: extracellular matrix organization and biogenesis; response to lipopolysaccharide; protein amino acid deamination. Disease: Exfoliation Syndrome

0.1 mg

290 USD