CCND3 Antibody | MyBioSource MBS850720 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CCND3 Antibody

catalog :

MBS850720

quantity :

0.1 mg

price :

290 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6H4

reactivity :

human, mouse

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS850720

products type :

Antibody

products full name :

CCND3 Antibody

products short name :

CCND3

products name syn :

CCND3; CCND3

other names :

G1/S-specific cyclin-D3 isoform 1; G1/S-specific cyclin-D3; G1/S-specific cyclin-D3; D3-type cyclin; G1/S-specific cyclin D3; cyclin D3

products gene name :

CCND3

other gene names :

CCND3; CCND3

uniprot entry name :

CCND3_HUMAN

clonality :

Monoclonal

clone :

6H4

host :

Mouse

reactivity :

Human, Mouse

sequence length :

211

form :

Ascitic fluid containing 0.03% sodium azide.

concentration :

100ug/100ul

storage stability :

Store at 4 degree C, for long term storage, store at -20 degree C.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000. Not yet tested in other applications.

other info2 :

Immunogen: Purified recombinant fragment of human CCND3 expressed in E. Coli. Species: Mouse IgG1

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products description :

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.

ncbi gi num :

209862835

ncbi acc num :

NP_001129489.1

ncbi gb acc num :

NM_001136017.3

ncbi mol weight :

32kDa

ncbi pathways :

B Cell Receptor Signaling Pathway (198909); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Cell Cycle Pathway (198811); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); Coregulation Of Androgen Receptor Activity Pathway (138085); Cyclin D Associated Events In G1 Pathway (105767); DNA Damage Response Pathway (198788); DNA Damage Response (only ATM Dependent) Pathway (198827)

ncbi summary :

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

uniprot summary :

CCND3: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/p27Kip1, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Component of the ternary complex cyclin D/CDK4/p27Kip1 required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either p21Cip1 or CDKN2A. Belongs to the cyclin family. Cyclin D subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell cycle regulation; Nuclear receptor co-regulator; Activator. Chromosomal Location of Human Ortholog: 6p21. Cellular Component: membrane; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; nucleus. Molecular Function: protein binding; cyclin-dependent protein kinase activity; protein kinase binding. Biological Process: T cell proliferation; positive regulation of cyclin-dependent protein kinase activity; cell division; positive regulation of protein amino acid phosphorylation; cell cycle; signal transduction

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage