catalog number :
MBS8507136
products full name :
RTN4RL1 Antibody (Rabbit Polyclonal)
products short name :
[RTN4RL1]
other names :
[Homo sapiens reticulon 4 receptor-like 1, mRNA; Reticulon-4 receptor-like 1; reticulon-4 receptor-like 1; reticulon 4 receptor like 1; Nogo receptor-like 2; Nogo-66 receptor homolog 2]
products gene name :
[RTN4RL1]
other gene names :
[RTN4RL1; RTN4RL1; NgR3; NGRH2; NgR3]
reactivity :
Reacts with: Human. Predicted: Rat, Mouse. Not yet tested in other species.
form :
Purified by protein affinity column containing 1% BSA and 0.02% NaN3
storage stability :
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
ELISA: 1:20,000-1:80,000. WB: 1:200-1:1,000. IHC: 1:100-1:500. Optimal dilutions/concentrations should be determined by the end use.
image1 heading :
Western Blot
image2 heading :
Immunohistochemistry
products description :
Rabbit polyclonal RTN4RL1 (1) antibody was raised against a recombinate human RTN4RL1 protein 36-252aa (BC128608).
ncbi mol weight :
49,065 Da
uniprot summary :
Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).