antibody

SORL1 Antibody

MBS850606

0.1 mg

290 USD

monoclonal

mouse

nonconjugated

7D7B11

western blot, ELISA, enzyme immunoassay

Antibody

SORL1 Antibody

SORL1

SORL1

sortilin-related receptor preproprotein; Sortilin-related receptor; sortilin-related receptor; mosaic protein LR11; LDLR relative with 11 ligand-binding repeats; sortilin-related receptor, L(DLR class) A repeats-containing; sorting protein-related receptor containing LDLR class A repeats; low-density lipoprotein receptor relative with 11 ligand-binding repeats; sortilin-related receptor, L(DLR class) A repeats containing; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; LDLR relative with 11 ligand-binding repeats; LR11; SorLA-1; Sorting protein-related receptor containing LDLR class A repeats; SorLA

SORL1

SORL1; SORL1; LR11; LRP9; SORLA; gp250; SorLA-1; C11orf32; C11orf32; LDLR relative with 11 ligand-binding repeats; LR11; SorLA

SORL_HUMAN

Monoclonal

7D7B11

Mouse

Human

2214

Ascitic fluid containing 0.03% sodium azide.

100ug/100ul

Store at 4 degree C. For long term storage, store at -20 degree C

Western Blot (WB), ELISA (EIA)

WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000. Not yet tested in other applications. Determining optimal working dilutions by titration test.

Immunogen: Purified recombinant fragment of SORL1 (aa2159-2214) expressed in E. Coli. Species: Mouse IgG

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Background: SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.

4507157

NP_003096.1

NM_003105.5

248,426 Da

This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.[provided by RefSeq, Sep 2010]

0.1 mg

290 USD