MCT1 Antibody | MyBioSource MBS8506036 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MCT1 Antibody

catalog :

MBS8506036

quantity :

0.1 mg

price :

310 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS8506036

products type :

Antibody

products full name :

MCT1 Antibody

products short name :

MCT1

products name syn :

SLC16A1

other names :

monocarboxylate transporter 1; Monocarboxylate transporter 1; monocarboxylate transporter 1; MCT 1; solute carrier family 16 member 1; solute carrier family 16 (monocarboxylic acid transporters), member 1; solute carrier family 16, member 1 (monocarboxylic acid transporter 1); solute carrier family 16 (monocarboxylate transporter), member 1; Solute carrier family 16 member 1

products gene name :

MCT1

other gene names :

SLC16A1; SLC16A1; MCT; HHF7; MCT1; MCT1; MCT 1

uniprot entry name :

MOT1_HUMAN

host :

Rabbit

reactivity :

Human Mouse Rat

sequence length :

500

specificity :

SLC16A 1 Antibody detects endogenous levels of total SLC16A 1.

purity :

Immunogen affinity purified

form :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCI, 0.02% sodium azide and 50% glycerol.Store at -20 degree C.Stable for 12 months from date of receipt

storage stability :

Store at -20 Degree C/1 year

tested application :

Western Blot (WB)

app notes :

WB 1:500-1:2000 . IHC 1:50-1:200

other info1 :

Immunogen: A synthetic peptide of human SLC16A 1.

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

ncbi gi num :

262073007

ncbi acc num :

NP_001159968.1

ncbi gb acc num :

NM_001166496.1

uniprot acc num :

P53985

ncbi mol weight :

54kD

ncbi pathways :

Basigin Interactions Pathway (106065); Cell Surface Interactions At The Vascular Wall Pathway (106062); Hemostasis Pathway (106028); Metabolism Pathway (477135); Proton-coupled Monocarboxylate Transport Pathway (161065); Pyruvate Metabolism Pathway (106205); Pyruvate Metabolism And Citric Acid (TCA) Cycle Pathway (106327); SLC-mediated Transmembrane Transport Pathway (119558); The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway (477137); Transmembrane Transport Of Small Molecules Pathway (106572)

ncbi summary :

The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]

uniprot summary :

MCT1: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Defects in SLC16A1 are the cause of symptomatic deficiency in lactate transport (SDLT); also known as erythrocyte lactate transporter defect. Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals. Defects in SLC16A1 are the cause of familial hyperinsulinemic hypoglycemia type 7 (HHF7); also known as exercise-induced hyperinsulinemic hypoglycemia. HHF7 is a dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. Protein type: Transporter, SLC family; Transporter; Mitochondrial; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 1p12. Cellular Component: centrosome; mitochondrion; membrane; integral to plasma membrane; plasma membrane; integral to membrane. Molecular Function: mevalonate transmembrane transporter activity; protein homodimerization activity; monocarboxylic acid transmembrane transporter activity; symporter activity; lactate transmembrane transporter activity; secondary active monocarboxylate transmembrane transporter activity. Biological Process: response to food; monocarboxylic acid transport; glucose homeostasis; cellular metabolic process; centrosome organization and biogenesis; mevalonate transport; lipid metabolic process; blood coagulation; pyruvate metabolic process; transmembrane transport; regulation of insulin secretion; leukocyte migration; behavioral response to nutrient. Disease: Erythrocyte Lactate Transporter Defect; Monocarboxylate Transporter 1 Deficiency; Hyperinsulinemic Hypoglycemia, Familial, 7

size1 :

0.1 mg

price1 :

310 USD

more info or order :

MyBioSource product webpage