product summary
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company name :
MyBioSource
product type :
antibody
product name :
HNF4A Antibody
catalog :
MBS8505949
quantity :
0.1 mL
price :
310 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS8505949 image 1
Western blot analysis of extracts of variouscell lines, using HNF4A antibody.
product information
catalog number :
MBS8505949
products type :
Antibody
products full name :
HNF4A Antibody
products short name :
[HNF4A]
products name syn :
[HNF4A; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14]
other names :
[hepatocyte nuclear factor 4-alpha 2; Hepatocyte nuclear factor 4-alpha; hepatocyte nuclear factor 4-alpha; hepatocyte nuclear factor 4 alpha; Nuclear receptor subfamily 2 group A member 1; Transcription factor 14; TCF-14; Transcription factor HNF-4]
products gene name :
[HNF4A]
other gene names :
[HNF4A; HNF4A; TCF; HNF4; MODY; FRTS4; MODY1; NR2A1; TCF14; HNF4a7; HNF4a8; HNF4a9; NR2A21; HNF4alpha; HNF4; NR2A1; TCF14; HNF-4-alpha; TCF-14]
clonality :
polyclonal
isotype :
IgG
host :
rabbit
reactivity :
Human, Mouse, Rat
sequence length :
474
purity :
Affinity purification
storage stability :
Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500-1:2000. IHC: 1:50-1:200
image1 heading :
Testing Data
other info1 :
Immunogen: A synthetic peptide of human HNF4A. Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
products categories :
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
products description :
Hepatocyte nuclear factor 4alpha (HNF4alpha) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver (1). HNF4alpha, in association with PGC-1alpha, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers (2, 3). Conditional knockout of the HNF4alpha gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels (4). Mutations in HNF4alpha have been linked to maturity-onset diabetes of the young (MODY) (5).
products references :
1. Sladek, F.M. et al. (1990) Genes Dev. 4, 2353-2365. 2. Yoon, J.C. et al. (2001) Nature 413, 131-138. 3. Rhee, J. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 4012-4017. 4. Hayhurst, G.P. et al. (2001) Mol. Cell Biol. 21, 1393-1403. 5. Ellard, S. and Colclough, K. (2006) Hum. Mutat. 27, 854-869.
ncbi gi num :
31077205
ncbi acc num :
NP_000448.3
ncbi gb acc num :
NM_000457.4
uniprot acc num :
P41235
ncbi mol weight :
52kDa
ncbi pathways :
AMPK Signaling Pathway (198868); Developmental Biology Pathway (477129); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); HIF-1-alpha Transcription Factor Network Pathway (138045); Integrated Pancreatic Cancer Pathway (711360); Maturity Onset Diabetes Of The Young Pathway (83096); Maturity Onset Diabetes Of The Young Pathway (508); Nuclear Receptor Transcription Pathway (105979)
ncbi summary :
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]
uniprot summary :
Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.
size1 :
0.1 mL
price1 :
310 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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