antibody

NAC1 Antibody

MBS850563

0.1 mg

290 USD

monoclonal

mouse

nonconjugated

6H2

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

NAC1 Antibody

NAC1

NAC1; BEND8; NAC-1; BTBD14B; FLJ37383; NACC1

nucleus accumbens-associated protein 1; Nucleus accumbens-associated protein 1; nucleus accumbens-associated protein 1; BEN domain containing 8; transcriptional repressor NAC1; BTB/POZ domain-containing protein 14B; nucleus accumbens associated 1, BEN and BTB (POZ) domain containing; BTB/POZ domain-containing protein 14B

NAC1

NACC1; NACC1; NAC1; BEND8; NAC-1; BTBD30; BTBD14B; BTBD14B; NAC1; NAC-1

NACC1_HUMAN

Monoclonal

6H2

Mouse

Human

527

Ascitic fluid containing 0.03% sodium azide.

100ug/100ul

Store at 4 degree C, for long term storage, store at -20 degree C.

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ELISA: Propose dilution 1/10000. Not yet tested in other applications.

Immunogen: Purified recombinant fragment of human NACC1 expressed in E. Coli. Species: Mouse IgG1

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Background: NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible for reward motivation and addictive behaviors. NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene expression in neuronal cells (3) and specifically co-represses other POZ/BTB proteins in the central nervous system. NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene. The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway. NAC1 has also been described as part of the extended transcriptional network in pluripotent cells that involves Oct-4, Sox2, Nanog, Sall1, KLF4 and Sall4. Tissue specificity:

16418383

NP_443108.1

NM_052876.3

58kDa

This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012]

0.1 mg

290 USD