catalog number :
MBS8505541
products full name :
Insulin Glargine Mouse Monoclonal Antibody
products short name :
[Insulin Glargine]
other names :
[insulin preproprotein; Insulin; insulin; insulin]
products gene name :
[INS]
other gene names :
[INS; INS; IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10]
specificity :
Antibody can detects Insulin Glargine protein
form :
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at-20 degree C for 1 year. Do not aliquot the antibody.
tested application :
ELISA (EIA)
app notes :
ELISA: 1:2,000-10,000
products description :
Insulin glargine, marketed by Sanofi-Aventis under the name Lantus, is a long-acting basal insulin analogue, given once daily to help control the blood sugar level of those with diabetes.
ncbi acc num :
NP_001278826.1
ncbi gb acc num :
NM_001291897.1
ncbi pathways :
AGE/RAGE Pathway (698754); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); ATF-2 Transcription Factor Network Pathway (138006); Adipogenesis Pathway (198832); Aldosterone-regulated Sodium Reabsorption Pathway (130626); Aldosterone-regulated Sodium Reabsorption Pathway (130590); Amyloids Pathway (366238); Arf6 Trafficking Events Pathway (137954); Cardiac Progenitor Differentiation Pathway (712094)
ncbi summary :
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
uniprot summary :
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.