OLIG2 Antibody | MyBioSource MBS850533 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

OLIG2 Antibody

catalog :

MBS850533

quantity :

0.1 mg

price :

290 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1G11

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS850533

products type :

Antibody

products full name :

OLIG2 Antibody

products short name :

OLIG2

products name syn :

BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19; OLIG2

other names :

oligodendrocyte transcription factor 2; Oligodendrocyte transcription factor 2; oligodendrocyte transcription factor 2; protein kinase C-binding protein 2; class B basic helix-loop-helix protein 1; class E basic helix-loop-helix protein 19; human protein kinase C-binding protein RACK17; basic domain, helix-loop-helix protein, class B, 1; oligodendrocyte-specific bHLH transcription factor 2; oligodendrocyte lineage transcription factor 2; Class B basic helix-loop-helix protein 1; bHLHb1; Class E basic helix-loop-helix protein 19; bHLHe19; Protein kinase C-binding protein 2; Protein kinase C-binding protein RACK17

products gene name :

OLIG2

other gene names :

OLIG2; OLIG2; BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19; BHLHB1; BHLHE19; PRKCBP2; RACK17; Oligo2; bHLHb1; bHLHe19

uniprot entry name :

OLIG2_HUMAN

clonality :

Monoclonal

clone :

1G11

host :

Mouse

reactivity :

Human, Mouse

sequence length :

323

form :

Ascitic fluid containing 0.03% sodium azide.

concentration :

100ug/100ul

storage stability :

Store at 4 degree C, for long term storage, store at -20 degree C.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

app notes :

WB: 1/500 - 1/2000, IHC: 1/200-1/1000, IF: 1/200-1/1000, ELISA: Propose dilution 1/10000. Not yet tested in other applications.

other info2 :

Immunogen: Purified recombinant fragment of human OLIG2 expressed in E. Coli. Species: Mouse IgG1

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products description :

Background: This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.

ncbi gi num :

17978475

ncbi acc num :

NP_005797.1

ncbi gb acc num :

NM_005806.3

ncbi mol weight :

32kDa

ncbi pathways :

Neural Crest Differentiation Pathway (672460)

ncbi summary :

This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]

uniprot summary :

OLIG2: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA. Protein type: Transcription factor; Oncoprotein. Chromosomal Location of Human Ortholog: 21q22.11. Cellular Component: cytoplasm; nucleus. Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein homodimerization activity; DNA binding. Biological Process: transcription from RNA polymerase II promoter; myelination; negative regulation of neuron differentiation; spinal cord oligodendrocyte cell fate specification; neuron fate commitment; positive regulation of oligodendrocyte differentiation; thalamus development; negative regulation of transcription from RNA polymerase II promoter; spinal cord motor neuron differentiation

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage