antibody

APOA1 Antibody

MBS850529

0.1 mg

280 USD

monoclonal

mouse

nonconjugated

[5F4F5]

western blot, ELISA, enzyme immunoassay

Antibody

APOA1 Antibody

[APOA1]

[MGC117399]

[apolipoprotein A-I isoform 1 preproprotein; Apolipoprotein A-I; apolipoprotein A-I; apolipoprotein A1; Apolipoprotein A1]

[APOA1]

[APOA1; APOA1; apo(a); Apo-AI; ApoA-I; ProapoA-I]

m

IgG1

[5F4F5]

Mouse

Human

267

Ascitic fluid containing 0.03% sodium azide.

Store at 4 degree C, for long term storage, store at-20 degree C

Western Blot (WB), ELISA (EIA).

WB: 1:500-1:2000. ELISA: 1:10000. Not yet tested in other applications. Determining optimal working dilutions by titration test.

Western Blot (WB)

Western Blot (WB)

Immunogen: Purified recombinant fragment of human APOA1 expressed in E. Coli.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

APOA1. apolipoprotein A-I, it is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in the Apolipoprotein A I gene are associated with HDL deficiency and Tangier disease. The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I. The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases.

4557321

NP_000030.1

NM_000039.2

P02647

25kDa

ABC-family Proteins Mediated Transport Pathway (106573); ABCA Transporters In Lipid Homeostasis Pathway (477112); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Amyloids Pathway (366238); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Chylomicron-mediated Lipid Transport Pathway (106157); Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911)

This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

0.1 mg

280 USD