MYC Antibody | MyBioSource MBS850523 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MYC Antibody

catalog :

MBS850523

quantity :

0.1 mg

price :

290 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7.00E+10

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS850523

products type :

Antibody

products full name :

MYC Antibody

products short name :

MYC

products name syn :

MRTL; c-Myc; bHLHe39

other names :

myc proto-oncogene protein; Myc proto-oncogene protein; myc proto-oncogene protein; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor; v-myc avian myelocytomatosis viral oncogene homolog; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64

products gene name :

MYC

other gene names :

MYC; MYC; MRTL; MYCC; c-Myc; bHLHe39; BHLHE39; bHLHe39

uniprot entry name :

MYC_HUMAN

clonality :

Monoclonal

clone :

7.00E+10

host :

Mouse

reactivity :

Human

sequence length :

454

form :

Ascitic fluid containing 0.03% sodium azide.

concentration :

100ug/100ul

storage stability :

Store at 4 degree C, for long term storage, store at -20 degree C.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000. Not yet tested in other applications.

other info2 :

Immunogen: Purified recombinant fragment of human MYC expressed in E. Coli. Species: Mouse IgG1

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products description :

Background: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. (provided by RefSeq).

ncbi gi num :

71774083

ncbi acc num :

NP_002458.2

ncbi gb acc num :

NM_002467.4

ncbi mol weight :

49kDa

ncbi pathways :

Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Apoptosis Pathway (198797); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); C-MYB Transcription Factor Network Pathway (138073); C-MYC Pathway (169344); CD40/CD40L Signaling Pathway (138061); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765)

ncbi summary :

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes. Protein type: Transcription factor; DNA-binding; Oncoprotein; Nucleolus. Chromosomal Location of Human Ortholog: 8q24.21. Cellular Component: nucleoplasm; protein complex; nucleolus; cytosol; nucleus. Molecular Function: protein dimerization activity; protein binding; DNA binding; protein complex binding; transcription factor binding; transcription factor activity. Biological Process: cellular iron ion homeostasis; oxygen transport; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; chromosome organization and biogenesis; positive regulation of fibroblast proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; response to gamma radiation; cell cycle arrest; response to drug; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; transcription, DNA-dependent; regulation of telomere maintenance; MAPKKK cascade; negative regulation of cell division; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; chromatin remodeling; ureteric bud branching; negative regulation of fibroblast proliferation; regulation of gene expression; energy reserve metabolic process; positive regulation of transcription from RNA polymerase II promoter; gene expression; response to DNA damage stimulus; positive regulation of epithelial cell proliferation; negative regulation of apoptosis. Disease: Burkitt Lymphoma

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage