EIF4E Antibody | MyBioSource MBS850484 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

EIF4E Antibody

catalog :

MBS850484

quantity :

0.1 mg

price :

290 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5D11

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, FACS, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS850484

products type :

Antibody

products full name :

EIF4E Antibody

products short name :

EIF4E

products name syn :

CBP; EIF4F; EIF4E1; EIF4EL1; MGC111573; EIF4E

other names :

eukaryotic translation initiation factor 4E isoform 3; Eukaryotic translation initiation factor 4E; eukaryotic translation initiation factor 4E; eIF-4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein; eukaryotic translation initiation factor 4E-like 1; eukaryotic translation initiation factor 4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein

products gene name :

EIF4E

other gene names :

EIF4E; EIF4E; CBP; EIF4F; AUTS19; EIF4E1; EIF4EL1; EIF4EL1; EIF4F; eIF-4E; eIF4E

uniprot entry name :

IF4E_HUMAN

clonality :

Monoclonal

clone :

5D11

host :

Mouse

reactivity :

Human

sequence length :

237

form :

Ascitic fluid containing 0.03% sodium azide.

concentration :

100ug/100ul

storage stability :

Store at 4 degree C, for long term storage, store at -20 degree C.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), ELISA (EIA)

app notes :

WB: 1/500 - 1/2000, IHC: 1/200-1/1000, IF: 1/200-1/1000, FC: 1/200-1/400, ELISA: Propose dilution 1/10000. Not yet tested in other applications.

other info2 :

Immunogen: Purified recombinant fragment of human EIF4E expressed in E. Coli. Species: Mouse IgG1

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products description :

Background: eIF4E, a protein modulates translation of maternal mRNAs in early embryos before the onset of zygotic transcription. eIF4E also influences the overall rate of translation. eIF4E binds to the 7 methyl GTP cap structure of eukaryotic mRNAs. Phosphorylation of eIF4E on serine 209 regulates the affinity of this protein for the 7 methyl GTP cap and/or RNA. Phosphorylation also enhances the interaction of eIF4E with eIF4G, which form a complex known as eIF4F. eIF4E phosphorylation is correlated with increased translational rate in a number of cell types. Several kinases are currently being investigated as potential regulators of eIF4E including PKC and/or the MAP kinase activated Mnk.

ncbi gi num :

194578907

ncbi acc num :

NP_001124150.1

ncbi gb acc num :

NM_001130678.1

ncbi mol weight :

25kDa

ncbi pathways :

Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway (105970); Alpha6-Beta4 Integrin Signaling Pathway (198807); Antiviral Mechanism By IFN-stimulated Genes Pathway (530760); BDNF Signaling Pathway (712093); Cap-dependent Translation Initiation Pathway (105967); Cytokine Signaling In Immune System Pathway (366171); Deadenylation Of MRNA Pathway (160994); Deadenylation-dependent MRNA Decay Pathway (160993); Eukaryotic Translation Initiation Pathway (105966); GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway (105973)

ncbi summary :

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

uniprot summary :

EIF4E: a protein of the eukaryotic initiation factor 4E family. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the EIF4F complex. Protein type: Translation initiation; Translation. Chromosomal Location of Human Ortholog: 4q23. Cellular Component: mRNA cap complex; stress granule; eukaryotic translation initiation factor 4F complex; cytoplasm; cytosol. Molecular Function: protein binding; eukaryotic initiation factor 4G binding; translation initiation factor activity; RNA cap binding. Biological Process: viral reproduction; translation; cytokine and chemokine mediated signaling pathway; positive regulation of mitotic cell cycle; regulation of translation; poly(A) tail shortening; mRNA export from nucleus; cellular protein metabolic process; translational initiation; insulin receptor signaling pathway; gene expression; G1/S transition of mitotic cell cycle; lung development; mRNA catabolic process, deadenylation-dependent decay. Disease: Autism, Susceptibility To, 19

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage