HIF1A Antibody | MyBioSource MBS850472 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

HIF1A Antibody

catalog :

MBS850472

quantity :

0.1 mg

price :

290 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1A3

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS850472

products type :

Antibody

products full name :

HIF1A Antibody

products short name :

HIF1A

products name syn :

HIF1; MOP1; PASD8; bHLHe78; HIF-1alpha; HIF1-ALPHA; HIF1A

other names :

hypoxia-inducible factor 1-alpha isoform 3; Hypoxia-inducible factor 1-alpha; hypoxia-inducible factor 1-alpha; HIF-1-alpha; member of PAS protein 1; ARNT interacting protein; ARNT-interacting protein; member of PAS superfamily 1; hypoxia-inducible factor1alpha; PAS domain-containing protein 8; basic-helix-loop-helix-PAS protein MOP1; class E basic helix-loop-helix protein 78; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78; bHLHe78; Member of PAS protein 1; PAS domain-containing protein 8

products gene name :

HIF1A

other gene names :

HIF1A; HIF1A; HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA; BHLHE78; MOP1; PASD8; HIF-1-alpha; HIF1-alpha; bHLHe78

uniprot entry name :

HIF1A_HUMAN

clonality :

Monoclonal

clone :

1A3

host :

Mouse

reactivity :

Human, Mouse, Monkey

sequence length :

850

form :

Ascitic fluid containing 0.03% sodium azide.

concentration :

100ug/100ul

storage stability :

Store at 4 degree C, for long term storage, store at -20 degree C.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

app notes :

WB: 1/500 - 1/2000, IHC: 1/200-1/1000, IF: 1/200-1/1000, ELISA: Propose dilution 1/10000. Not yet tested in other applications.

other info2 :

Immunogen: Purified recombinant fragment of human HIF1A expressed in E. Coli. Species: Mouse IgG1

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products description :

Background: Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified. (provided by RefSeq) Tissue specificity: Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors.

ncbi gi num :

340545531

ncbi acc num :

NP_001230013.1

ncbi gb acc num :

NM_001243084.1

ncbi mol weight :

120kDa

ncbi pathways :

AGE/RAGE Pathway 698754!!Adipogenesis Pathway 198832!!Angiogenesis Pathway 198772!!Cellular Response To Hypoxia Pathway 645259!!Cellular Responses To Stress Pathway 645258!!Circadian Clock Pathway 187173!!Disease Pathway 530764!!FBXW7 Mutants And NOTCH1 In Cancer Pathway 771596!!HIF-1 Signaling Pathway 695200!!HIF-1-alpha Transcription Factor Network Pathway 138045

ncbi summary :

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]

size :

0.1 mg

price :

290 USD

more info or order :

MyBioSource product webpage