catalog number :
MBS8504332
products full name :
LC3 Antibody
products short name :
[LC3]
other names :
[microtubule-associated proteins 1A/1B light chain 3A isoform a; Microtubule-associated proteins 1A/1B light chain 3A; microtubule-associated proteins 1A/1B light chain 3A; microtubule associated protein 1 light chain 3 alpha; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B light chain 3 A; MAP1A/MAP1B LC3 A; Microtubule-associated protein 1 light chain 3 alpha]
products gene name :
[LC3]
other gene names :
[MAP1LC3A; MAP1LC3A; LC3; LC3A; ATG8E; MAP1ALC3; MAP1BLC3; MAP1A/MAP1B LC3 A]
ncbi acc num :
NP_115903.1
ncbi gb acc num :
NM_032514.3
ncbi mol weight :
14,493 Da
ncbi pathways :
Senescence And Autophagy Pathway (198780)
ncbi summary :
MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]
uniprot summary :
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600).