catalog number :
MBS850429
products full name :
Foxp3 Antibody
products short name :
Foxp3
products name syn :
JM2; AIID; IPEX; PIDX; XPID; DIETER; Foxp3
other names :
forkhead box protein P3 isoform b; Forkhead box protein P3; forkhead box protein P3; scurfin; FOXP3delta7; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; forkhead box P3; Scurfin
products gene name :
Foxp3
other gene names :
FOXP3; FOXP3; JM2; AIID; IPEX; PIDX; XPID; DIETER; IPEX
uniprot entry name :
FOXP3_HUMAN
reactivity :
Human, Mouse
form :
Purified antibody in PBS containing 0.03% sodium azide.
concentration :
100ug/100ul
storage stability :
Store at 4 degree C, for long term storage, store at -20 degree C
tested application :
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA(EIA)
app notes :
WB: 1/500 - 1/2000, IHC:1/200 - 1/1000, IF: 1/200 - 1/1000, ELISA: Propose dilution 1/10000. Not yet tested in other applications. Determining optimal working dilutions by titration test.
other info2 :
Immunogen: Purified recombinant fragment of human Foxp3 expressed in E. Coli. Species: Mouse IgG1
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products description :
Background: The transcription factor Foxp family includes Foxp1, Foxp2, and Foxp3. The Foxp3 (50KDa)plays a key role in CD4(+) CD25(+) regulatory T cell function and represents a specific marker for these cells. Despite its strong association with regulatory T cell function, in humans little is known about the frequency of CD4(+) CD25(+) cells that express FOXP3 protein nor the distribution of these cells in vivo. FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.
ncbi acc num :
NP_001107849.1
ncbi gb acc num :
NM_001114377.1
ncbi mol weight :
44,407 Da
ncbi pathways :
Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway 137993!!IL2 Signaling Events Mediated By STAT5 Pathway 137988!!Inflammatory Bowel Disease (IBD) Pathway 842771!!Inflammatory Bowel Disease (IBD) Pathway 842797
ncbi summary :
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]