FOXO1 Antibody | MyBioSource MBS8504211 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FOXO1 Antibody

catalog :

MBS8504211

quantity :

0.1 mL

price :

310 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of NIH/3T3 cellline, using FOXO1antibody.

image 2 :

Immunohistochemistry of paraffin-embeddedhuman tonsil tissue using FOXO1 antibody.

product information

catalog number :

MBS8504211

products type :

Antibody

products full name :

FOXO1 Antibody

products short name :

[FOXO1]

products name syn :

[FKH1; FKHR; FOXO1A]

other names :

[forkhead box protein O1; Forkhead box protein O1; forkhead box protein O1; forkhead box O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma]

products gene name :

[FOXO1]

other gene names :

[FOXO1; FOXO1; FKH1; FKHR; FOXO1A; FKHR; FOXO1A]

clonality :

polyclonal

isotype :

IgG

host :

rabbit

reactivity :

Human, Mouse, Rat

sequence length :

655

purity :

Affinity purification

storage stability :

Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500-1:2000. IHC: 1:50-1:100

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: A synthetic peptide of human FOXO1. Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

products categories :

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

products description :

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. Interacts with LRPPRC. Interacts with RUNX2; the interaction inhibits RUNX2 transcriptional activity and mediates the IGF1/insulin-dependent BGLAP expression in osteoblasts Interacts with PPP2R1A; the interaction regulates the dephosphorylation of FOXO1 at Thr-24 and Ser-256 leading to its nuclear import.

ncbi gi num :

9257222

ncbi acc num :

NP_002006.2

ncbi gb acc num :

NM_002015.3

uniprot acc num :

Q12778

ncbi mol weight :

70kDa

ncbi pathways :

AGE/RAGE Pathway (698754); AKT Phosphorylates Targets In The Nucleus Pathway (106476); AKT-mediated Inactivation Of FOXO1A Pathway (106333); Adaptive Immune System Pathway (366160); Adipogenesis Pathway (198832); Androgen Receptor Signaling Pathway (198806); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); B Cell Receptor Signaling Pathway (198909); CXCR4-mediated Signaling Events Pathway (137910); Class I PI3K Signaling Events Mediated By Akt Pathway (138020)

ncbi summary :

uniprot summary :

Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner. Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling ().

size1 :

0.1 mL

price1 :

310 USD

more info or order :

MyBioSource product webpage