CD44 Antibody | MyBioSource MBS850417 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CD44 Antibody

catalog :

MBS850417

quantity :

0.1 mg

price :

280 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[8E2F3]

reactivity :

human, mouse

more info or order :

MyBioSource product webpage

image

image 1 :

Figure 1. Western blot analysis using CD44 mouse mAb against truncated Trx-CD44 recombinant protein (1) and GST-CD44 (aa628-699) recombinant protein (2).

image 2 :

Figure 2. Western blot analysis using CD44 mouse mAb against Hela (1) and HUVE-12(2) cell lysate.

image 3 :

Figure 3. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissues, showing membrane localization with DAB staining using CD44 mouse mAb.

product information

catalog number :

MBS850417

products type :

Antibody

products full name :

CD44 Antibody

products short name :

[CD44]

products name syn :

[IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL]

other names :

[CD44 antigen isoform 1; CD44 antigen; CD44 antigen; CD44 molecule (Indian blood group); CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD_antigen: CD44]

products gene name :

[CD44]

other gene names :

[CD44; CD44; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; LHR; MDU2; MDU3; MIC4; ECMR-III; PGP-1; PGP-I]

clonality :

isotype :

IgG1

clone :

[8E2F3]

host :

Mouse

reactivity :

Human, Mouse

sequence length :

742

form :

Ascitic fluid containing 0.03% sodium azide.

storage stability :

Store at 4°C, for long term storage, store at -20°C.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA). Not yet tested in other applications.

app notes :

Determining optimal working dilutions by titrations test. WB: 1:500-1:2000. IF: 1:200-1:1000. ELISA. Propose dilution 1:10000.

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot (WB)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Purified recombinant fragment of human CD44 (628-699) expressed in E. Coli.

products categories :

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

products description :

CD44, also known as IN, LHRMIC4, CDW44, HCELL. It is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.

ncbi gi num :

48255935

ncbi acc num :

NP_000601.3

ncbi gb acc num :

NM_000610.3

uniprot acc num :

P16070

ncbi mol weight :

82kDa

ncbi pathways :

Cytokine Signaling In Immune System Pathway (366171); Disease Pathway (530764); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); Glycosaminoglycan Metabolism Pathway (645297); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Hyaluronan Metabolism Pathway (645298)

ncbi summary :

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

uniprot summary :

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function ().

size1 :

0.1 mg

price1 :

280 USD

more info or order :

MyBioSource product webpage