antibody

Androgen receptor Antibody

MBS850365

0.1 mg

290 USD

monoclonal

mouse

nonconjugated

2H8

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Androgen receptor Antibody

Androgen receptor

NR3C4; KD; AIS; SMAX1; HUMARA; AR

androgen receptor isoform 1; Androgen receptor; androgen receptor; dihydrotestosterone receptor; androgen nuclear receptor variant 2; nuclear receptor subfamily 3 group C member 4; androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4

AR; AR; KD; AIS; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA; DHTR; NR3C4

ANDR_HUMAN

Monoclonal

2H8

Mouse

Human

920

Ascitic fluid containing 0.03% sodium azide.

100ug/100ul

Store at 4 degree C, for long term storage, store at -20 degree C.

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ELISA: Propose dilution 1/10000. Not yet tested in other applications.

Immunogen: Purified recombinant fragment of human AR expressed in E. Coli. Species: Mouse IgG1

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Background: The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor which is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the androgen receptor is as a DNA binding transcription factor which regulates gene expression; however, the androgen receptor has other functions as well. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype.

21322252

NP_000035.2

NM_000044.3

110kDa

Alpha6-Beta4 Integrin Signaling Pathway 198807!!Androgen Receptor Signaling Pathway 198806!!Coregulation Of Androgen Receptor Activity Pathway 138085!!FOXA1 Transcription Factor Network Pathway 137979!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!IL-6 Signaling Pathway 198864!!Integrated Breast Cancer Pathway 219801!!Integrated Pancreatic Cancer Pathway 711360!!Nongenotropic Androgen Signaling Pathway 138048

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

0.1 mg

290 USD