ROR1 Antibody | MyBioSource MBS850362 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ROR1 Antibody

catalog :

MBS850362

quantity :

0.1 mg

price :

290 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2H6

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS850362

products type :

Antibody

products full name :

ROR1 Antibody

products short name :

ROR1

products name syn :

ROR1

other names :

tyrosine-protein kinase transmembrane receptor ROR1 isoform 2; Tyrosine-protein kinase transmembrane receptor ROR1; tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase, receptor-related 1; receptor tyrosine kinase-like orphan receptor 1; Neurotrophic tyrosine kinase, receptor-related 1

products gene name :

ROR1

other gene names :

ROR1; ROR1; NTRKR1; dJ537F10.1; NTRKR1

uniprot entry name :

ROR1_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

2H6

host :

Mouse

reactivity :

Human

sequence length :

393

form :

Ascitic fluid containing 0.03% sodium azide.

concentration :

100ug/100ul

storage stability :

Store at 4 degree C. For long term storage, store at -20 degree C

tested application :

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

app notes :

WB: 1/500 - 1/2000, IF: 1/200 - 1/1000, ELISA: Propose dilution 1/10000. Not yet tested in other applications. Determining optimal working dilutions by titration test.

other info2 :

Immunogen: Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells. Species: Mouse IgG1

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products description :

Background: ROR1, a type I membrane protein, is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. The ROR-family receptor tyrosine kinases consist of two structurally related proteins, ROR1 and ROR2. These proteins are characterized by having intracellular tyrosine kinase domains, which are highly related to Trk-family kinases, extracellular Frizzled-like cysteine-rich domains (CRDs) and Kringle domains. The ROR family members are highly conserved among species, such as C. elegans, Drosophila, Xenopus and mammals. ROR1 and ROR2 are both involved in organogenesis with particular emphasis in neuronal differentiation. Increased expression of ROR1 in acute lymphoblastic leukemias (ALLs) as well as chronic lymphocytic leukemias (CLLs) implicate this protein as a potential tool for targeted immunotherapy in these diseases.

ncbi gi num :

134152686

ncbi acc num :

NP_001077061.1

ncbi gb acc num :

NM_001083592.1

ncbi mol weight :

101kDa

ncbi pathways :

Nuclear Receptors Pathway (198848); PCP/CE Pathway (941395); Signal Transduction Pathway (477114); Signaling By Wnt Pathway (106510); WNT5A-dependent Internalization Of FZD2, FZD5 And ROR2 Pathway (941398); Beta-catenin Independent WNT Signaling Pathway (941394)

ncbi summary :

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

uniprot summary :

ROR1: Tyrosine-protein kinase receptor whose role is not yet clear. Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; TK group; Ror family. Chromosomal Location of Human Ortholog: 1p31.3. Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; receptor complex. Molecular Function: Wnt-protein binding; protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding. Biological Process: peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage