GDF15 Antibody | MyBioSource MBS8503584 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

GDF15 Antibody

catalog :

MBS8503584

quantity :

0.1 mL

price :

310 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of SW620 cell lysate using GDF15 antibody.

product information

catalog number :

MBS8503584

products type :

Antibody

products full name :

GDF15 Antibody

products short name :

[GDF15]

products name syn :

[GDF15; GDF-15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB; Growth/differentiation factor 15; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor]

other names :

[growth/differentiation factor 15 preproprotein; Growth/differentiation factor 15; growth/differentiation factor 15; growth differentiation factor 15; Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor]

products gene name :

[GDF15]

other gene names :

[GDF15; GDF15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; MIC1; PDF; PLAB; PTGFB; GDF-15; MIC-1; NAG-1; NRG-1]

clonality :

polyclonal

isotype :

IgG

host :

rabbit

reactivity :

Human, Mouse, Rat

sequence length :

308

purity :

Affinity purification

storage stability :

Store at-20°C or -80°C. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500-1:2000. IHC: 1:50-1:200

image1 heading :

Western Blot (WB)

other info1 :

Immunogen: Recombinant protein of human GDF15. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

other info2 :

Calculated MW: 34.15kDa

products categories :

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

products description :

Macrophage inhibitory cytokine-1 (Mic-1), also termed GDF15 (1), PTGF-beta (2), PLAB (3), PDF (4), and NAG-1 (5), is a divergent member of the transforming growth factor-beta (TGF-beta) superfamily (6). Like other family members, Mic-1 is synthesized as an inactive precursor that undergoes proteolytic processing involving removal of an N-terminal hydrophobic signal sequence followed by cleavage at a conserved RXXR site generating an active C-terminal domain that is secreted as a dimeric protein. Mic-1 is highly expressed in the placenta and is also dramatically increased by cellular stress, acute injury, inflammation, and cancer. In the brain, Mic-1 is found in the choroid plexus and is secreted into the cerebrospinal fluid (7). It is also a transcriptional target of the p53 tumor suppressor protein and may serve as a biomarker for p53 activity (8, 9). During tumor progression, Mic-1 has various effects on apoptosis, differentiation, angiogenisis, and metastasis, and may also contribute to weight loss during cancer (10, 11).

products references :

1. Strelau, J. et al. (2000) J Neurosci 20, 8597-603. 2. Yokoyama-Kobayashi, M. et al. (1997) J Biochem 122, 622-6. 3. Hromas, R. et al. (1997) Biochim Biophys Acta 1354, 40-4. 4. Paralkar, V.M. et al. (1998) J Biol Chem 273, 13760-7. 5. Baek, S.J. et al. (2001) J Biol Chem 276, 33384-92. 6. Bootcov, M.R. et al. (1997) Proc Natl Acad Sci USA 94, 11514-9. 7. Strelau, J. et al. (2000) J Neural Transm Suppl, 273-6. 8. Kannan, K. et al. (2000) FEBS Lett 470, 77-82. 9. Yang, H. et al. (2003) Mol Cancer Ther 2, 1023-9. 10. Johnen, H. et al. (2007) Nat Med 13, 1333-40. 11. Bauskin, A.R. et al. (2006) Cancer Res 66, 4983-6.

ncbi gi num :

153792495

ncbi acc num :

NP_004855.2

ncbi gb acc num :

NM_004864.3

uniprot acc num :

Q99988

ncbi pathways :

Direct P53 Effectors Pathway (137939)

ncbi summary :

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016]

size1 :

0.1 mL

price1 :

310 USD

more info or order :

MyBioSource product webpage