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Apolipoprotein A1 Antibody

MBS850334

0.1 mL

290 USD

Antibody

Apolipoprotein A1 Antibody

[Apolipoprotein A1]

[apolipoprotein A1, partial; Apolipoprotein A-I; apolipoprotein A-I; apolipoprotein A1; Apolipoprotein A1]

[APOA1; APOA1; apo(a); Apo-AI; ApoA-I; ProapoA-I]

Rabbit

67

This antibody is produced by immunizing mouses with rabbit IgG.

ProG purified

In 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol.

Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.

Immunoprecipitation (IP), Western Blot (WB), ELISA (EIA)

IP: 1:1,000-2,000. WB: 1:1,000-2,000. ELISA: 1:2,000-5,000

Western Blot

Preservative: 0.05% Sodium Azide. Cellular Localization: Serum/Plasma

Positive Control: Rabbit IgG

The fundamental structure of IgG contains two identical heavy chains of about 50 kDa and two identical light chains of about 25 kDa, thus tetrameric quaternary structure. Light chain, which is usually same in a natural IgG molecule, includeskappachain and lambda chain, but kappaor lambda antibody can exist in one body simultaneously. A heavy chain includes Fab-and Fc-Fragments. This antibody can recognize rabbit IgG Fc fragments of heavy chains.

4960066

AAD34604.1

~50kDa

ABC-family Proteins Mediated Transport Pathway (106573); ABCA Transporters In Lipid Homeostasis Pathway (477112); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Amyloids Pathway (366238); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Chylomicron-mediated Lipid Transport Pathway (106157); Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911)

This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

0.1 mL

290 USD