FASN Antibody | MyBioSource MBS850333 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FASN Antibody

catalog :

MBS850333

quantity :

0.05 mg

price :

225 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS850333

products type :

Antibody

products full name :

FASN Antibody

products short name :

FASN

other names :

Homo sapiens fatty acid synthase (FASN), mRNA; Fatty acid synthase; fatty acid synthase; short chain dehydrogenase/reductase family 27X, member 1; fatty acid synthase

products gene name :

FASN

other gene names :

FASN; FASN; FAS; OA-519; SDR27X1; FAS

uniprot entry name :

FAS_HUMAN

clonality :

Monoclonal

host :

Mouse

reactivity :

Human

sequence length :

8481

purity :

Protein G-Sepharose affinity purified

form :

Liquid

concentration :

50ug/50ul

storage stability :

Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

ELISA: 1/5000 - 1/20000, WB: 1/100-1/2000

other info1 :

Relevance: FAS (Fatty Acid Synthase) is a central enzyme in de novo lipogenesis. FAS is a target for SREBP and is upregulated by LXR activation; it is also one of the accepted markers for insulin resistance, SREBP and LXR activation. Perservative: 0.02% Sodium Azide and 50% glycerol, 1% BSA, PBS, pH7.4.

other info2 :

Immunogen: Recombinant fragment of human FASN (C-terminus). Cellular Localization: Cytoplasmic. Pathway: insulin resistance

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products description :

Background: Mouse monoclonal IgG to FASN

ncbi gi num :

41872630

ncbi acc num :

NP_004095.4

ncbi gb acc num :

NM_004104.4

ncbi mol weight :

273,427 Da

ncbi pathways :

AMPK Signaling Pathway (198868); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Activation Of Gene Expression By SREBF (SREBP) Pathway (685552); ChREBP Activates Metabolic Gene Expression Pathway (106104); Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway (906000); Defective BTD Causes Biotidinase Deficiency Pathway (906015); Defective CD320 Causes Methylmalonic Aciduria Pathway (906012); Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway (906001); Defective GIF Causes Intrinsic Factor Deficiency Pathway (906004)

ncbi summary :

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]

uniprot summary :

FASN: a multifunctional enzyme. Catalyzes the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. Protein type: Hydrolase; EC 3.1.2.14; Lipid Metabolism - fatty acid biosynthesis; Lyase; EC 2.3.1.38; Acetyltransferase; EC 1.1.1.100; EC 2.3.1.39; EC 2.3.1.41; EC 1.3.1.39; EC 4.2.1.59; EC 2.3.1.85; Oxidoreductase. Chromosomal Location of Human Ortholog: 17q25. Cellular Component: Golgi apparatus; mitochondrion; membrane; glycogen granule; cytoplasm; plasma membrane; melanosome; cytosol. Molecular Function: fatty-acid synthase activity; protein homodimerization activity; myristoyl-[acyl-carrier-protein] hydrolase activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; zinc ion binding; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; [acyl-carrier-protein] S-acetyltransferase activity; drug binding; 3-oxoacyl-[acyl-carrier-protein] reductase activity; protein binding; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; [acyl-carrier-protein] S-malonyltransferase activity; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity. Biological Process: osteoblast differentiation; vitamin metabolic process; acetyl-CoA metabolic process; pantothenate metabolic process; positive regulation of cellular metabolic process; energy reserve metabolic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; fatty acid metabolic process; water-soluble vitamin metabolic process; fatty acid biosynthetic process

size1 :

0.05 mg

price1 :

225 USD

size2 :

0.1 mg

price2 :

290

more info or order :

MyBioSource product webpage