antibody

SOD1 Antibody

MBS850323

0.1 mg

290 USD

monoclonal

mouse

nonconjugated

6F5

human, mouse

western blot, ELISA, immunocytochemistry, flow cytometry, FACS, enzyme immunoassay

Antibody

SOD1 Antibody

SOD1

ALS; SOD; ALS1; IPOA; homodimer

superoxide dismutase; Superoxide dismutase [Cu-Zn]; superoxide dismutase [Cu-Zn]; superoxide dismutase [Cu-Zn]; SOD, soluble; indophenoloxidase A; Cu/Zn superoxide dismutase; superoxide dismutase, cystolic; epididymis secretory protein Li 44; superoxide dismutase 1, soluble; Superoxide dismutase 1; hSod1

SOD1

SOD1; SOD1; ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer; hSod1

SODC_HUMAN

Monoclonal

6F5

Mouse

Human, Mouse

154

Ascitic fluid containing 0.03% sodium azide.

100ug/100ul

Store at 4 degree C. For long term storage, store at -20 degree C

Western Blot (WB), Immunofluorescence (IF), Flow Cytometry (FC/FACS) ELISA (EIA)

WB: 1/500 - 1/2000, IF: 1/200 - 1/1000, FC: 1/200 - 1/400, ELISA: Propose dilution 1/10000. Not yet tested in other applications. Determining optimal working dilutions by titration test.

Immunogen: Purified recombinant fragment of human SOD1 expressed in E. Coli. Species: Mouse IgG1

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Background: SOD1 (superoxide dismutase 1, soluble), also known as ALS. The protein binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis (ALS), a progressive degenerative disease of motor neurons. Rare transcript variants have been reported for this gene.

4507149

NP_000445.1

NM_000454.4

18kDa

AGE/RAGE Pathway (698754); Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Cellular Responses To Stress Pathway (645258); Detoxification Of Reactive Oxygen Species Pathway (941400); Dopamine Metabolism Pathway (920995); FOXA1 Transcription Factor Network Pathway (137979); Folate Metabolism Pathway (198833); Hemostasis Pathway (106028)

The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]

SOD1: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Homodimer; non-disulfide linked. Homodimerization may take place via the ditryptophan cross-link at Trp-33. The pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not. The pathogenic variants ALS1 Arg-86 and Ala-94 interact with MARCH5, whereas wild-type protein does not. Belongs to the Cu-Zn superoxide dismutase family. Protein type: EC 1.15.1.1; Oxidoreductase; Mitochondrial; Nuclear receptor co-regulator; Apoptosis. Chromosomal Location of Human Ortholog: 21q22.11. Cellular Component: dendrite cytoplasm; extracellular space; protein complex; mitochondrion; extracellular region; mitochondrial intermembrane space; cytosol; nucleoplasm; extracellular matrix; cell soma; mitochondrial matrix; cytoplasm; plasma membrane; peroxisome; cytoplasmic vesicle; nucleus. Molecular Function: identical protein binding; protein binding; protein homodimerization activity; copper ion binding; zinc ion binding; chaperone binding; superoxide dismutase activity; Rac GTPase binding; protein phosphatase 2B binding. Biological Process: positive regulation of catalytic activity; positive regulation of apoptosis; activation of MAPK activity; cellular iron ion homeostasis; myeloid cell homeostasis; retrograde axon cargo transport; response to antibiotic; muscle maintenance; retinal homeostasis; glutathione metabolic process; neurofilament cytoskeleton organization and biogenesis; regulation of mitochondrial membrane potential; positive regulation of superoxide release; negative regulation of neuron apoptosis; placenta development; positive regulation of cytokine production; response to drug; platelet activation; cell aging; regulation of organ growth; transmission of nerve impulse; response to reactive oxygen species; response to ethanol; response to heat; heart contraction; superoxide release; relaxation of vascular smooth muscle; removal of superoxide radicals; locomotory behavior; response to organic substance; sensory perception of sound; platelet degranulation; ovarian follicle development; regulation of blood pressure; auditory receptor cell stereocilium organization and biogenesis; response to axon injury; anterograde axon cargo transport; negative regulation of cholesterol biosynthetic process; response to nutrient levels; response to superoxide; thymus development; regulation of T cell differentiation in the thymus; response to amphetamine; superoxide metabolic process; myelin maintenance in the peripheral nervous system; regulation of multicellular organism growth; response to copper ion; response to hydrogen peroxide; spermatogenesis; blood coagulation; regulation of protein kinase activity; embryo implantation; hydrogen peroxide biosynthetic process. Disease: Amyotrophic Lateral Sclerosis 1

0.1 mg

290 USD