FABP4 Antibody | MyBioSource MBS850313 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FABP4 Antibody

catalog :

MBS850313

quantity :

0.1 mg

price :

290 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9B8D

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, FACS, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS850313

products type :

Antibody

products full name :

FABP4 Antibody

products short name :

FABP4

products name syn :

aP2; A-FABP; FABP4

other names :

fatty acid-binding protein, adipocyte; Fatty acid-binding protein, adipocyte; fatty acid-binding protein, adipocyte; fatty acid-binding protein 4; adipocyte lipid-binding protein; epididymis secretory protein Li 104; adipocyte-type fatty acid-binding protein; fatty acid binding protein 4, adipocyte; Adipocyte lipid-binding protein; ALBP; Adipocyte-type fatty acid-binding protein; A-FABP; AFABP; Fatty acid-binding protein 4

products gene name :

FABP4

other gene names :

FABP4; FABP4; aP2; ALBP; AFABP; A-FABP; HEL-S-104; ALBP; A-FABP; AFABP

uniprot entry name :

FABP4_HUMAN

clonality :

Monoclonal

clone :

9B8D

host :

Mouse

reactivity :

Human

sequence length :

132

form :

Ascitic fluid containing 0.03% sodium azide.

concentration :

100ug/100ul

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), ELISA (EIA)

app notes :

WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000. Not yet tested in other applications. Determining optimal working dilutions by titration test.

other info2 :

Immunogen: Purified recombinant fragment of FABP4 expressed in E. Coli. Species: Mouse IgG1

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products description :

Background: Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long chain fatty acids, their coenzymes and other hydrophobic ligands and small molecules in the cytoplasm. It is thought that the role of these proteins includes fatty acid uptake, intracellular lipid transport and metabolism. FABP4 encodes the fatty acid binding protein found in adipocytes. FABP4 knockout mice fed a high-fat and high-calorie diet become obese but develop neither insulin resistance nor diabetes, suggesting that this protein might be a link between obesity and insulin resistance and diabetes A related study in humans indicated a similar pattern, suggesting that FABP4 may be a potential therapeutic target in the treatment of these disorders.

ncbi gi num :

4557579

ncbi acc num :

NP_001433.1

ncbi gb acc num :

NM_001442.2

ncbi mol weight :

14kDa

ncbi pathways :

Developmental Biology Pathway (477129); Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway (106121); Lipid Digestion, Mobilization, And Transport Pathway (106111); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); PPAR Signaling Pathway (83042); PPAR Signaling Pathway (450); Transcriptional Regulation Of White Adipocyte Differentiation Pathway (205243)

ncbi summary :

FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]

uniprot summary :

FABP4: a lipid transport protein that is the predominant fatty acid binding protein found in adipocytes. Also expressed in macrophages. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Homodimer. Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Interacts with PPARG. Monomer. FABP4 knockout mice fed a high-fat and high-calorie diet become obese but develop neither insulin resistance nor diabetes, suggesting that this protein might be a link between obesity and insulin resistance and diabetes. Mice deficient in both FABP4 and ApoE show protection against atherosclerosis when compared with mice deficient only in ApoE. Mice carrying a FABP4 genetic variant exhibit both reduced FABP4 expression and a reduced potential for developing type 2 diabetes and coronary heart disease. A related study in humans indicated a similar pattern, suggesting that FABP4 may be a potential therapeutic target in the treatment of these disorders. Belongs to the calycin superfamily,fatty-acid binding protein (FABP) family. Protein type: Lipid-binding. Chromosomal Location of Human Ortholog: 8q21. Cellular Component: cytoplasm; lipid particle; nucleus. Molecular Function: transporter activity; fatty acid binding. Biological Process: cholesterol homeostasis; transport; white fat cell differentiation; triacylglycerol catabolic process; brown fat cell differentiation; negative regulation of protein kinase activity; cytokine production; negative regulation of transcription, DNA-dependent; positive regulation of inflammatory response

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage