product summary
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company name :
MyBioSource
product type :
other
product name :
DEPDC5 Antibody
catalog :
MBS8502990
quantity :
0.1 mg
price :
320 USD
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS8502990 image 1
image 2 :
MyBioSource MBS8502990 image 2
product information
catalog number :
MBS8502990
products type :
Antibody
products full name :
DEPDC5 Antibody
products short name :
[DEPDC5]
other names :
[Homo sapiens DEP domain containing 5, mRNA; GATOR complex protein DEPDC5; GATOR complex protein DEPDC5; DEP domain containing 5; DEP domain-containing protein 5]
products gene name :
[DEPDC5]
other gene names :
[DEPDC5; DEPDC5; DEP.5; FFEVF; FFEVF1]
reactivity :
Human . Predicted : Rat, Mouse. Not yet tested in other species.
sequence length :
2397
form :
Rabbit anti-DEPDC5 antibody purified by protein A column containing 0.02% NaN 3
storage stability :
Already reconstituted in 200 ul sterile H 2 O. The antibody is stable for at least one year when stored at -20°C after reconstitution.
tested application :
For research use only.
app notes :
ELISA 1:20,000-80,000. Western blot analysis 1:200-1:1000. Immunohistochemistry 1:100-1:500. Optimal dilutions/concentrations should be determined by end user.
image1 heading :
Testing Data
image2 heading :
Testing Data #2
other info1 :
Host Note: Rabbit polyclonal DEPDC5 (1) antibody was raised against a recombinate human DEPDC5 protein 129aa-332aa
ncbi gi num :
34785517
ncbi acc num :
BC057797
ncbi summary :
This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
uniprot summary :
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
size1 :
0.1 mg
price1 :
320 USD
size2 :
0.2 mL
price2 :
320
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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