catalog number :
MBS8502984
products full name :
DHODH Antibody
products short name :
[DHODH]
other names :
[dihydroorotate dehydrogenase (quinone), mitochondrial; Dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate dehydrogenase (quinone); Dihydroorotate oxidase]
products gene name :
[DHODH]
other gene names :
[DHODH; DHODH; URA1; POADS; DHOdehase; DHOdehase]
image1 heading :
Immunohistochemistry
image2 heading :
Western Blot
ncbi acc num :
NP_001352.2
ncbi gb acc num :
NM_001361.4
ncbi mol weight :
42,867 Da
ncbi pathways :
Metabolism Pathway (477135); Metabolism Of Nucleotides Pathway (106263); Pyrimidine Biosynthesis Pathway (161056); Pyrimidine Metabolism Pathway (106281); Pyrimidine Metabolism Pathway (82946); Pyrimidine Metabolism Pathway (309); Uridine Monophosphate Biosynthesis, Glutamine (+ PRPP) = UMP Pathway (524498); Uridine Monophosphate Biosynthesis, Glutamine (+ PRPP) = UMP Pathway (468244)
ncbi summary :
The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
uniprot summary :
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.MiscellaneousThe identification of DHODH defects as the cause of postaxial acrofacial dysostosis (POADS) was obtained via exome sequencing (PubMed:19915526), demonstrating that this method is a powerful tool for identifying genes underlying rare Mendelian disorders. Exome sequencing consists of targeted resequencing of all protein-coding subsequences, which requires around 5% as much sequencing as a whole human genome.