OCT4 Antibody | MyBioSource MBS850273 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

OCT4 Antibody

catalog :

MBS850273

quantity :

0.1 mg

price :

290 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5F7

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS850273

products type :

Antibody

products full name :

OCT4 Antibody

products short name :

4-Oct

products name syn :

OCT3; OCT4; OTF3; OTF4; OTF-3; Oct-3; Oct-4; MGC22487; POU5F1

other names :

POU domain, class 5, transcription factor 1 isoform 2; POU domain, class 5, transcription factor 1; POU domain, class 5, transcription factor 1; octamer-binding protein 3; octamer-binding protein 4; POU domain transcription factor OCT4; octamer-binding transcription factor 3; POU-type homeodomain-containing DNA-binding protein; POU class 5 homeobox 1; Octamer-binding protein 3; Oct-3; Octamer-binding protein 4; Oct-4; Octamer-binding transcription factor 3; OTF-3

products gene name :

4-Oct

other gene names :

POU5F1; POU5F1; OCT3; OCT4; OTF3; OTF4; OTF-3; Oct-3; Oct-4; OCT3; OCT4; OTF3; Oct-3; Oct-4; OTF-3

uniprot entry name :

PO5F1_HUMAN

clonality :

Monoclonal

clone :

5F7

host :

Mouse

reactivity :

Human

sequence length :

190

form :

Ascitic fluid containing 0.03% sodium azide.

concentration :

100ug/100ul

storage stability :

Store at 4 degree C, for long term storage, store at -20 degree C.

tested application :

Western Blot (WB), ELISA (EIA) . Not yet tested in other applications.

app notes :

WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000

other info2 :

Immunogen: Synthesized peptide of human Oct4. Species: Mouse IgG1

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products description :

Background: This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6;22)(p21;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. (provided by RefSeq).Tissue specificity: Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.

ncbi gi num :

291167757

ncbi acc num :

NP_001167002.1

ncbi gb acc num :

NM_001173531.2

ncbi mol weight :

45kDa

ncbi pathways :

Cardiac Progenitor Differentiation Pathway (712094); Developmental Biology Pathway (477129); HIF-2-alpha Transcription Factor Network Pathway (137956); POU5F1 (OCT4), SOX2, NANOG Activate Genes Related To Proliferation Pathway (980456); POU5F1 (OCT4), SOX2, NANOG Repress Genes Related To Differentiation Pathway (980457); SIDS Susceptibility Pathways (198901); Signaling Pathways Regulating Pluripotency Of Stem Cells (1026136); Signaling Pathways Regulating Pluripotency Of Stem Cells (1033502); Transcriptional Regulation Of Pluripotent Stem Cells Pathway (980455); Wnt Signaling Pathway And Pluripotency (198847)

ncbi summary :

This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]

uniprot summary :

Oct4: Transcription factor that binds to the octamer motif (5 -ATTTGCAT-3 ). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Interacts with UBE2I and ZSCAN10. Interacts with PKM2. Interacts with WWP2. Transcriptional activity is positively regulated by PKM2. Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues. Belongs to the POU transcription factor family. Class- 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 6p21.31. Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus; cytosol. Molecular Function: protein binding; miRNA binding; DNA binding; sequence-specific DNA binding; ubiquitin protein ligase binding; transcription factor binding; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; anatomical structure morphogenesis; blastocyst development; regulation of asymmetric cell division; regulation of transcription, DNA-dependent; regulation of gene expression; somatic stem cell maintenance; endodermal cell fate specification; response to wounding; positive regulation of transcription from RNA polymerase II promoter; mRNA transcription from RNA polymerase II promoter

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage