catalog number :
MBS850266
products full name :
CEA Antibody
products short name :
CEA
products name syn :
CEA; CD66e; DKFZp781M2392; CEACAM5
other names :
carcinoembryonic antigen-related cell adhesion molecule 5 preproprotein; Carcinoembryonic antigen-related cell adhesion molecule 5; carcinoembryonic antigen-related cell adhesion molecule 5; meconium antigen 100; carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100; CD_antigen: CD66e
other gene names :
CEACAM5; CEACAM5; CEA; CD66e; CEA; CEA
uniprot entry name :
CEAM5_HUMAN
form :
Ascitic fluid containing 0.03% sodium azide.
concentration :
100ug/100ul
storage stability :
Store at 4 degree C, for long term storage, store at -20 degree C.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
app notes :
WB: 1/500 - 1/2000, IHC: 1/200-1/1000, ELISA: Propose dilution 1/10000. Not yet tested in other applications.
other info2 :
Immunogen: Purified recombinant fragment of human CEA expressed in E. Coli. Species: Mouse IgG1
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products description :
Background: Carcino Embryonic Antigen (CEA) is synthesised during development in the fetal gut, and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. Antibodies to CEA are useful in identifying the origin of various metastatic adenocarcinomas and in distinguishing pulmonary adenocarcinomas (60 to 70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+).The carcinoembryonic antigen (CEA) is a member of a large family of glycoproteins and a useful tumor marker for adenocarcinoma.Tissue specificity: Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
ncbi acc num :
NP_004354.2
ncbi gb acc num :
NM_004363.3
ncbi summary :
Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (MIM 109770).[supplied by OMIM, Oct 2009]
uniprot summary :
CEACAM5: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily. CEA family. Protein type: Immunoglobulin superfamily; Membrane protein, GPI anchor; Membrane protein, integral. Chromosomal Location of Human Ortholog: 19q13.1-q13.2. Cellular Component: integral to plasma membrane; basolateral plasma membrane. Molecular Function: identical protein binding; protein homodimerization activity. Biological Process: homotypic cell-cell adhesion; negative regulation of apoptosis