product summary
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company name :
MyBioSource
product type :
antibody
product name :
KI67 Antibody
catalog :
MBS850259
quantity :
0.1 mg
price :
280 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
[9C12B2]
reactivity :
human
application :
western blot, ELISA, enzyme immunoassay
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS850259 image 1
Figure 1. Western blot analysis using Ki67 mouse mAb against truncated Trx-Ki67 recombinant protein(1), truncated Ki67 (aa3118-3256)-His recombinant protein(2) and truncated Ki67 (aa3118-3256)-hIgGFc transfected CHO-K1 cell lysate(3).
product information
catalog number :
MBS850259
products type :
Antibody
products full name :
KI67 Antibody
products short name :
[KI67]
products name syn :
[KIA; Ki-67; MKI67]
other names :
[proliferation marker protein Ki-67 isoform 2; Proliferation marker protein Ki-67; proliferation marker protein Ki-67; marker of proliferation Ki-67; Antigen identified by monoclonal antibody Ki-67]
products gene name :
[KI67]
other gene names :
[MKI67; MKI67; KIA; MIB-; MIB-1; PPP1R105; Antigen KI-67Curated; Antigen Ki67Curated]
clonality :
m
isotype :
IgG1
clone :
[9C12B2]
host :
Mouse
reactivity :
Human
sequence length :
2896
form :
Ascitic fluid containing 0.03% sodium azide.
storage stability :
Store at 4 degree C, for long term storage, store at-20 degree C
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
WB: 1:500-1:2000. ELISA: 1:10000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Purified recombinant fragment of Ki167 (aa3118-3256) expressed in E. Coli.
products categories :
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
products description :
Ki67. antigen identified by monoclonal antibody Ki-67. Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation.
ncbi gi num :
225543215
ncbi acc num :
NP_001139438.1
ncbi gb acc num :
NM_001145966.1
uniprot acc num :
P46013
ncbi mol weight :
319,444 Da
ncbi summary :
This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]
uniprot summary :
Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
size1 :
0.1 mg
price1 :
280 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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