CYP7A1 Antibody | MyBioSource MBS850235 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CYP7A1 Antibody

catalog :

MBS850235

quantity :

0.05 mg

price :

225 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS850235

products type :

Antibody

products full name :

CYP7A1 Antibody

products short name :

CYP7A1

other names :

Homo sapiens cytochrome P450, family 7, subfamily A, polypeptide 1 (CYP7A1), mRNA; Cholesterol 7-alpha-monooxygenase; cholesterol 7-alpha-monooxygenase; cytochrome P450 7A1; cholesterol 7-alpha-hydroxylase; cytochrome P450, subfamily VIIA polypeptide 1; cytochrome P450, family 7, subfamily A, polypeptide 1; CYPVII; Cholesterol 7-alpha-hydroxylase; Cytochrome P450 7A1

products gene name :

CYP7A1

other gene names :

CYP7A1; CYP7A1; CP7A; CYP7; CYPVII; CYP7

uniprot entry name :

CP7A1_HUMAN

clonality :

Monoclonal

host :

Mouse

reactivity :

Human

sequence length :

2877

purity :

Protein G-Sepharose affinity purified.

form :

Liquid

concentration :

50ug/50ul

storage stability :

Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

ELISA: 1/5000 - 1/20000, WB: 1/100-1/2000

other info1 :

Relevance: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. Perservative: 0.02% Sodium Azide and 50% glycerol, 1% BSA, PBS, pH7.4.

other info2 :

Immunogen: Recombinant fragment of human CYP7A1 (C-terminus). Cellular Localization: Endoplasmic reticulum. Pathway: cholesterol catabolic pathway

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products description :

Background: Mouse monoclonal IgG to CYP7A1

ncbi gi num :

13787185

ncbi acc num :

NP_000771.1

ncbi gb acc num :

NM_000780.2

ncbi mol weight :

57,661 Da

ncbi pathways :

Bile Acid And Bile Salt Metabolism Pathway (106144); Bile Acid Biosynthesis, Cholesterol = Cholate/chenodeoxycholate Pathway (413432); Bile Acid Biosynthesis, Cholesterol = Cholate/chenodeoxycholate Pathway (468297); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Biological Oxidations Pathway (105698); Cytochrome P450 - Arranged By Substrate Type Pathway (105700); Drug Induction Of Bile Acid Pathway (698755); Endogenous Sterols Pathway (105701); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977)

ncbi summary :

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010]

uniprot summary :

CYP7A1: Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis. Belongs to the cytochrome P450 family. Protein type: Endoplasmic reticulum; EC 1.14.13.17; Lipid Metabolism - primary bile acid biosynthesis; Oxidoreductase. Chromosomal Location of Human Ortholog: 8q11-q12. Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle. Molecular Function: cholesterol 7-alpha-monooxygenase activity; iron ion binding; heme binding. Biological Process: bile acid biosynthetic process; cholesterol homeostasis; bile acid metabolic process; xenobiotic metabolic process; cellular lipid metabolic process; cholesterol catabolic process; transmembrane transport; sterol metabolic process

size1 :

0.05 mg

price1 :

225 USD

size2 :

0.1 mg

price2 :

290

more info or order :

MyBioSource product webpage